AI Article Synopsis
- - CK1 kinases are essential for various cellular functions as they bind to and phosphorylate many protein substrates, showing a preference for those that have already been phosphorylated.
- - They play a significant role in the Wnt signaling pathway, working alongside other kinases, and their activity is also influenced by posttranslational modifications like autophosphorylation.
- - The text offers an overview of CK1 biology, focusing on how scaffold binding and kinase regulation affect Wnt signaling and circadian rhythms.
Article Abstract
The CK1 family of serine/threonine kinases regulates diverse cellular processes, through binding to and phosphorylation a myriad of protein substrates. CK1 prefers substrates primed by prior phosphorylation, and works closely with other kinases in the Wnt pathway. CK1 is itself regulated by posttranslational modification, including autophosphorylation. We provide a brief overview of the fundamentals of CK1 biology with an emphasis on scaffold binding and kinase regulation in Wnt signaling and circadian rhythms.
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| http://dx.doi.org/10.1016/j.biocel.2010.12.004 | DOI Listing |
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