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A case of levocetirizine-induced liver injury.
Clin Mol Hepatol
December 2016
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Levocetirizine is a second-generation nonsedative antihistaminic agent that has been demonstrated to be safe and effective for treating allergic disease. There was only one case report of levocetirizine-induced liver toxicity, but a liver biopsy was not performed. In this article, we present the first case of levocetirizine-induced liver injury with histologic findings.
View Article and Find Full Text PDFCetirizine-induced hepatotoxicity: case series and review of the literature.
Gastroenterol Rep (Oxf)
August 2018
Department of Gastroenterology, Adnan Menderes University, School of Medicine, Aydin, Turkey.
Drug-induced liver damage is a frequently encountered clinical table caused by many drugs. Cetirizine is a widely preferred and prescribed antihistaminic agent for allergic disorders due to its non-sedative properties. In view of the literature, we present four cases of hepatotoxicity due to cetirizine use.
View Article and Find Full Text PDFSignal detection of potentially drug-induced acute liver injury in children using a multi-country healthcare database network.
Drug Saf
February 2014
Department of Medical Informatics, Erasmus University Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands,
Background: Data mining in spontaneous reporting databases has shown that drug-induced liver injury is infrequently reported in children.
Objectives: Our objectives were to (i) identify drugs potentially associated with acute liver injury (ALI) in children and adolescents using electronic healthcare record (EHR) data; and (ii) to evaluate the significance and novelty of these associations.
Methods: We identified potential cases of ALI during exposure to any prescribed/dispensed drug for individuals <18 years old from the EU-ADR network, which includes seven databases from three countries, covering the years 1996-2010.
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