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Impact of combination chemotherapy with praziquantel and gentamicin or doxycycline on acute hepatic and intestinal schistosomiasis in BALB/c mice.
Exp Parasitol
March 2025
Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Minas Gerais (MG), Brazil.
Background And Aims: Marked divergences in the immunological mechanisms that regulate the pathophysiology of acute and chronic schistosomiasis have a direct influence on pathological outcomes and antiparasitic chemotherapy responses at different stages of Schistosoma mansoni infection. In that way, this study evaluated the impact of combination antiparasitic chemotherapy, involving gentamicin (GEN) and doxycycline (DOX) in combination with praziquantel (PZQ) on the development of acute hepatic and intestinal schistosomiasis in mice.
Methods: BALB/cmice were randomized into five experimental groups, and the formation of hepatic and intestinal granulomas was evaluated by histopathological and histomorphometric analyses, quantification of hepatic parasite load, and biochemical parameters (ALT, AST, ALP, and albumin).
An integrated mass drug administration against hymenolepiasis and schistosomiasis in Sudan.
Parasites Hosts Dis
February 2025
Department of Microbiology, Dongguk University College of Medicine, Gyeongju 38066, Korea.
Hymenolepis nana, commonly known as the dwarf tapeworm, affects 50 to 75 million people worldwide. To date, no studies have explored the disease burden of H. nana infection in Sudan.
View Article and Find Full Text PDFBiochemical, coagulation, and platelet count profiles among Schistosoma mansoni infected patients attending at selected Dembiya health institutions, Northwest Ethiopia.
BMC Microbiol
March 2025
Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Background: Schistosomiasis is a parasitic disease that causes coagulation disorders and biochemical abnormalities. This is due to liver failure, platelet destruction, disruption of blood flow, and endothelial function by the schistosomes. However, there is no adequate data on biochemical and coagulation profiles and platelet count of patients infected with Schistosoma mansoni in Dembiya Selected Health Institutions.
View Article and Find Full Text PDFResidual transmission of schistosomiasis in Ndikinimeki Health District (Centre Region, Cameroon) despite implementation of complementary control strategies: Prospects for elimination.
Parasite Epidemiol Control
February 2025
Higher Institute for Scientific and Medical Research (ISM), Yaoundé, Cameroon.
Schistosomiasis control currently relies on school-based preventive chemotherapy (PC) with praziquantel, which has been proven, unfortunately, insufficient to interrupt disease transmission in areas with persistent transmission. In the Ndikinimeki Health District (Centre Region, Cameroon), complementary strategies (community-based preventive chemotherapy, water sanitation, hygiene, and health education) have also been implemented to accelerate the interruption of schistosomiasis transmission in this focus. The assessment of the impact of this package of interventions revealed that only a few individuals were still infected with .
View Article and Find Full Text PDFAntischistosomal Potential of Animal-Derived Natural Products and Compounds.
Microorganisms
February 2025
Laboratório de Ciclo Celular, Instituto Butantan, São Paulo 05503-900, SP, Brazil.
Schistosomiasis is a neglected tropical disease that affects over 240 million people worldwide. Currently, praziquantel is the only drug recommended by the World Health Organization for treatment. However, cases of drug resistance have been reported, which indicates an urgent need for new therapeutics.
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