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Cunning simplicity of a stoichiometry driven protein folding thesis.
J Biomol Struct Dyn
February 2011
Institute of Protein Research, Russian Academy of Science, Institutskaya str 4, Pushchino, Moscow Region 142290, Russia.
The masticatory system is widely adaptable and tolerant especially in young people ; this characteristic can be helpful but it can also incur risks because there are limits to everything. Guided solely by the insubstantial support provided by data derived from evidence-based medicine, a researcher would have to be both excessively clever and unusually cunning to define the borderline between physiological and pathological occlusion. Accordingly, the optimization of masticatory function through the intermediary of efficient occlusal interaction of upper and lower teeth remains a fundamental common sense objective of all dental treatment.
View Article and Find Full Text PDFCunning simplicity of a hierarchical folding.
J Biomol Struct Dyn
December 2002
Institute of Protein Research, Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russia.
A hierarchic scheme of protein folding does not solve the Levinthal paradox since it cannot provide a simultaneous explanation for major features observed for protein folding: (i) folding within non-astronomical time, (ii) independence of the native structure on large variations in the folding rates of given protein under different conditions, and (iii) co-existence, in a visible quantity, of only the native and the unfolded molecules during folding of moderate size (single-domain) proteins. On the contrary, a nucleation mechanism can account for all these major features simultaneously and resolves the Levinthal paradox.
View Article and Find Full Text PDFCunning simplicity of protein folding landscapes.
Protein Eng
August 2001
Institute of Protein Research, Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russia.
Funnel-like landscapes are widely used to visualize protein folding. It might seem that any funnel-like energy landscape helps to avoid the 'Levinthal paradox', i.e.
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