AI Article Synopsis
- The synthesis of new nanoscopic structures is made possible by combining efficient polymerizations and modular "click" reactions, leading to innovative materials.
- A new class of bivalent-brush polymers, featuring azide groups and branched polyethylene glycol (PEG) chains, was created using advanced polymerization techniques.
- These polymers successfully loaded the chemotherapy drug doxorubicin (DOX) using a "click" reaction, showing effectiveness in targeting human cancer cells when the drug was released.
Article Abstract
The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by "graft-through" ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click-to" coupling of a photocleavable doxorubicin (DOX)-alkyne derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6-∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically effective against human cancer cells.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077470 | PMC |
| http://dx.doi.org/10.1021/ja108441d | DOI Listing |
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