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PDGFBB facilitates tumorigenesis and malignancy of lung adenocarcinoma associated with PI3K-AKT/MAPK signaling.
Sci Rep
February 2024
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Lung adenocarcinoma (LUAD) remains one of the most aggressive tumors and the efficacy of conventional treatment has been bleak. Nowadays, gene-targeted therapy has become a new favorite in tumor therapy. Herein, we investigated the effect of platelet derived growth factor BB (PDGFBB) on LUAD.
View Article and Find Full Text PDFThe road to death: Caspases, cleavage, and pores.
Sci Adv
April 2023
Physiological Chemistry Department, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA. Email:
Vishva Dixit recounts his favorite discoveries after 30-plus years studying the proteins that allow infected, damaged, or obsolete cells to die.
View Article and Find Full Text PDFSynergistic Combination of the Total Steroidal Saponins from the Berries of Black Nightshade and Adriamycin to Overcome Leukemia Multidrug Resistance.
J Agric Food Chem
February 2023
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
The berries of black nightshade ( L.) are consumed as a favorite fruit in some regions and have been reported to possess a range of biological activities. Previous studies have found that the steroidal saponins from the berries of (SN) showed potential antileukemic activity, although the underlying mechanism remains to be revealed.
View Article and Find Full Text PDFYeast as a tool to decipher the molecular mechanisms underlying the functions of Bcl-2 family.
Explor Target Antitumor Ther
April 2022
UMR5095, CNRS, Université de Bordeaux, 33077 Bordeaux, France.
The budding yeast a favorite model in biology, does not contain any protein of the Bcl-2 family. From initial experiments with two-hybrid systems to the heterologous expression of human Bcl-2 family members, and the characterization of several forms of yeast programmed cell death, it has however always been a powerful tool to gain information on the mechanisms of apoptosis in general and on Bcl-2 family in particular. This is a short survey of 25 years of experiments that have provided, and at times initiated, insights into the molecular mechanisms underlying the function of Bcl-2 family members.
View Article and Find Full Text PDFL-carnitine in a certain concentration increases expression of cell surface marker CD34 and apoptosis in the rat bone marrow CD34 hematopoietic stem cells.
Iran J Vet Res
January 2021
Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Stem cell based therapy has been encouraged as an attractive method in regenerative medicine. Poor survival and maintenance of the cells transferred into the damaged tissue are broadly accepted as serious barriers to enhancing the efficacy of regenerative medicine. For this reason, some antioxidants such as L-carnitine (LC) are used as a favorite strategy to improve cell survival and retention properties.
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