[Correlation between the refractory periods and threshold potentials and the spike programming in cortical neurons].

Aim: To investigate the intrinsic mechanisms underlying spike programming at pyramidal neurons and interneurons in layer II/III of sensorimotor cortex.

Methods: Electrical signals at the cortical neurons were recorded in current clamp model with multi-clamp700B Amplifiers. Signals were inputted into pClamp and Origin for data acquisition and analyses.

Results: Compared to pyramidal neurons, interneurons express the higher capacity of spikes and the more stability of spike programming, which are mechanistically caused by lower threshold potentials and shorter refractory periods.

Conclusion: The refractory periods and threshold potentials directly influence the programming of sequential spikes.