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[Inulicin inhibits activation and expression of vascular remodeling enzymes induced by de-endothelium]. | LitMetric

[Inulicin inhibits activation and expression of vascular remodeling enzymes induced by de-endothelium].

Zhongguo Ying Yong Sheng Li Xue Za Zhi

Hebei Laboratory of Medical Biotechnology, Institute of Basic Medicine, Heibei Medical University, Shijiazhuang 050017, China.

Published: May 2008

AI Article Synopsis

Article Abstract

Aim: To observe the effects of inulicin on the neointimal hyperplasia and expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) after balloon injury in rat aorta.

Methods: The intimal hyperplasia model was replicated by balloon injury. The histological changes in vascular wall were observed by HE staining. MMP-2 activation was tested by gelatin zymogram analysis; MMP-2 and TIMP-2 expression was detected by Western blot and immunohistochemistry analysis.

Results: Neointimal hyperplasia induced by balloon injury was significantly inhibited by inulicin. The proteolytic activity and the expression of MMP-2 and ratio of MMP-2 and TIMP-2 were also returned to control level by inulicin after balloon injury.

Conclusion: Inulicin inhibits hyperplasia of neointima by modulating the balance of MMP-2 and TIMP-2.

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