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Integration of CRISPR/dCas9-Based methylation editing with guide positioning sequencing identifies dynamic changes of mrDEGs in breast cancer progression.
Cell Mol Life Sci
January 2025
Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Dynamic changes in DNA methylation are prevalent during the progression of breast cancer. However, critical alterations in aberrant methylation and gene expression patterns have not been thoroughly characterized. Here, we utilized guide positioning sequencing (GPS) to conduct whole-genome DNA methylation analysis in a unique human breast cancer progression model: MCF10 series of cell lines (representing benign/normal, atypical hyperplasia, and metastatic carcinoma).
View Article and Find Full Text PDFReports an error in "One thought too few: An adaptive rationale for punishing negligence" by Arunima Sarin and Fiery Cushman (, 2024[Apr], Vol 131[3], 812-824). In the original article, the copyright attribution was incorrectly listed, and the Creative Commons CC BY license disclaimer was incorrectly omitted from the author note. The correct copyright is "© 2024 The Author(s)," and the omitted disclaimer is present as: Open Access funding provided by University College London: This work is licensed under a Creative Commons Attribution 4.
View Article and Find Full Text PDFTrends in Retraction of Orthopaedic Research Articles.
J Bone Joint Surg Am
December 2024
Department of Orthopaedics and Physical Performance, University of Rochester Medical Center, Rochester, New York.
Background: Despite the use of in-depth peer-review processes, there occasionally are issues with published manuscripts that require retraction. The purpose of the present study was to explore the reasons for the retraction of orthopaedic research articles, with consideration of the journal impact factor and the orthopaedic subspecialty.
Methods: In 2023, a database search was conducted for retracted papers written in the English language in the orthopaedic literature.
Cardiovascular Events Risk in Office-Masked Nocturnal Hypertension Defined by Home Blood Pressure Monitoring.
JACC Adv
November 2024
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Background: Nocturnal home blood pressure monitoring (HBPM) may identify people at higher cardiovascular disease (CVD) risk than expected.
Objectives: The aim of this study was to examine the association between office-masked nocturnal hypertension, defined by HBPM, and CVD risk in a clinical practice-based population.
Methods: Prospective observational study including Japanese high cardiovascular-risk participants.
Predicting two-year return-to-sport failure after medial patellofemoral ligament reconstruction in patellar dislocation patients with bone abnormalities.
J Orthop Surg Res
November 2024
Department of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, 050051, Hebei, China.
Purpose: To develop a comprehensive and validated personalized scoring system based on anatomical characteristics to predict the probability of failure to return to sport after medial patellofemoral ligament reconstruction in patients with patellar dislocation.
Methods: 312 patients with medial patellofemoral ligament reconstruction in our hospital from 2013 to 2023 were included. Demographic and anatomical characteristics were collected retrospectively.
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