AI Article Synopsis
- The study investigated the antioxidant and radical scavenging abilities of various 2-[4-(substituted piperazin-/piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole compounds.
- Compounds 11-30 and 33 were tested against free radicals like DPPH and superoxide anions, along with their effect on lipid peroxidation in rat liver microsomes.
- Among these, compound 33 showed the highest inhibition of lipid peroxidation (83%) at a specific concentration, which correlated with its antimicrobial effectiveness against Staphylococcus aureus and Candida albicans.
Article Abstract
Antioxidant and radical scavenging properties of a series of 2-[4-(substituted piperazin-/piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole derivatives were examined. Free radical scavenging properties of compounds 11-30 and 33 were evaluated for the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide anion radical. In addition the inhibitory effects on the NADPH-dependent lipid peroxidation levels were determined by measuring the formation of 2-thiobarbituric acid reactive substances (TBARS) using rat liver microsomes. Compound 33 which has a p-fluorobenzyl substitutent at position 1 exhibited the strongest inhibition (83%) of lipid peroxidation at a concentration of 10(-3) M, while the nonsubstituted analogue 13 caused 57% inhibition. This result is fairly consistent with the antimicrobial activity results against both Staphylococcus aureus and Candida albicans.
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| http://dx.doi.org/10.1515/znc-2010-9-1002 | DOI Listing |
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