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Effect of ethyl acetate extract of the whole plant Clerodendrum phlomidis on improving bleomycin (BLM)-induced idiopathic pulmonary fibrosis (IPF) in Rats: In vitro and in vivo research.
Int Immunopharmacol
January 2025
Department of Biological Sciences (Regulatory Toxicology), National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana 500037, India.
Idiopathic pulmonary fibrosis (IPF) is a prevalent chronic lung condition of unknown etiology characterized by fibrosis and inflammation. Lung scarring progresses owing to cytokines and immune cells that promote inflammation and fibrosis in idiopathic pulmonary fibrosis (IPF). The anti-inflammatory and anti-fibrotic properties of the ethyl acetate extract of Clerodendrum phlomidis (CPEA), derived from the Indian plant "agnimantha," are recognized in traditional Ayurvedic medicine.
View Article and Find Full Text PDFComprehensive profiling of traditional herbomineral formulation Manasamitra vatakam in rat brain following oral administration and in-silico screening of the identified compound for anti-Alzheimer's activity.
J Ethnopharmacol
February 2025
Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Health Science Campus, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India. Electronic address:
Ethnopharmacological Relevance: Multi-targeted drug therapy has received substantial attention for the treatment of diseases of multifactorial origin, such as neurodegenerative diseases. Manasamitra vatakam (MMV) is a traditional Ayurvedic formulation used to improve cognitive impairment and mental illness. Here we have used a unique method for leveraging the barrier properties of the intestinal and blood-brain barrier (BBB) to screen and identify the bioactive molecules against Alzheimer's disease (AD).
View Article and Find Full Text PDFArticle Synopsis
- * A case study involved a 32-year-old male who received Ayurvedic Uttar Basti therapy over nine months, which includes the administration of medicated oil through the urethra.
- * The treatment led to significant improvements in urinary flow metrics, including a 25% increase in Maximum Flow rate and a 143% increase in Average Flow rate, also allowing the patient to avoid further surgery.
Curcumin and Gut Microbiota: A Narrative Overview with Focus on Glycemic Control.
Int J Mol Sci
July 2024
Obesity and Work Centre, Occupational Medicine Unit, Clinica del Lavoro L. Devoto, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Article Synopsis
- * Curcumin has low absorption in the body but significantly interacts with gut microbiota, which is essential for overall health and plays a role in conditions like type 2 diabetes and metabolic syndrome.
- * Restoring a healthy gut microbiome can improve blood sugar regulation and reduce insulin resistance, highlighting the potential of curcumin in managing metabolic disorders.
Elucidating the anti-cancer potential of essential oil against non-small cell lung cancer: A multifaceted approach involving GC-MS profiling, network pharmacology, and molecular dynamics simulations.
Heliyon
March 2024
Centre for Biotechnology, Siksha 'O' Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar, 751003, India.
(Buch.-Ham.) T.
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