Clinical inquiries. Which patients benefit from lowering LDL to <100 mg/dL?

Patients who have coronary heart disease (CHD) or are at high risk for CHD should aim for a low-density lipoprotein (LDL) target of <100 mg/dL. An LDL target of <70 mg/dL is an option for very-high-risk patients (strength of recommendation [SOR]: C, expert opinion). The evidence also indicates that high-risk patients benefit from a statin-preferably in high doses-regardless of their baseline LDL or degree of LDL reduction with treatment (SOR: A, a large randomized controlled trial [RCT] and meta-analyses).