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Evaluation of N-NOSE as a surveillance tool for recurrence in gastric and esophageal cancers: a prospective cohort study.
BMC Cancer
December 2024
Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Objective: Early detection of recurrent gastric and esophageal cancers remains a critical challenge. Innovative and non-invasive cancer screening technologies, such as N-NOSE, can improve early detection. N-NOSE is a urine-based scent test that leverages the olfactory abilities of the nematode C.
View Article and Find Full Text PDFTargeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment.
Foods
December 2024
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Odorant receptors (ORs) have long been thought to serve as chemosensors located on the cilia of olfactory sensory neurons (OSNs) in the olfactory epithelium, where they recognize odorant molecules and comprise the largest family of seven transmembrane-domain G protein-coupled receptors (GPCRs). Over the last three decades, accumulating evidence has suggested that ORs are distributed in a variety of peripheral tissues beyond their supposed typical tissue expression in the olfactory epithelium. These ectopic ORs play a role in regulating various cellular, physiological, and pathophysiological phenomena in the body, such as regulation of hypertension, hepatic glucose production, cancer development, and chronic skin disease.
View Article and Find Full Text PDFPartial role of volatile organic compounds in behavioural responses of mice to bedding from cancer-affected congeners.
Biol Open
July 2024
ISEM, Univ Montpellier, CNRS, IRD, Montpellier, France.
Tumours induce changes in body odours. We compared volatile organic compounds (VOCs) in soiled bedding of a lung adenocarcinoma male mouse model in which cancer had (CC) versus had not (NC) been induced by doxycycline at three conditions: before (T0), after 2 weeks (T2; early tumour development), after 12 weeks (T12; late tumour development) of the induction. In an earlier study, wild-derived mice behaviourally discriminated between CC and NC soiled bedding at T2 and T12.
View Article and Find Full Text PDFApplication of electronic nose technology in the diagnosis of gastrointestinal diseases: a review.
J Cancer Res Clin Oncol
August 2024
Department of Gastroenterology, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, China.
Electronic noses (eNoses) are electronic bionic olfactory systems that use sensor arrays to produce response patterns to different odors, thereby enabling the identification of various scents. Gastrointestinal diseases have a high incidence rate and occur in 9 out of 10 people in China. Gastrointestinal diseases are characterized by a long course of symptoms and are associated with treatment difficulties and recurrence.
View Article and Find Full Text PDFInhalable Stem Cell Exosomes Promote Heart Repair After Myocardial Infarction.
Circulation
August 2024
Department of Biomedical Engineering (D.Z., S.L., S.H., K.C.), Columbia University, New York, NY.
Article Synopsis
- Exosome therapy has potential for heart repair after injury, but challenges like short lifespan and unclear targets limit its clinical use; the study introduces a new method called SCENT (stem cell-derived exosome nebulization therapy) for delivering exosomes through inhalation post-myocardial infarction (MI).
- Researchers tested SCENT in mice and pigs, finding it improves heart function, reduces tissue scarring, and promotes heart cell growth; advanced imaging techniques helped confirm these benefits.
- Mechanistic studies indicate that SCENT works by modifying the metabolism in endothelial cells, leading to better heart energy use, as seen in both mouse and pig models, showcasing its potential efficacy and safety for cardiac repair.
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