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An Active-Site Bro̷nsted Acid-Base Catalyst Destabilizes Mandelate Racemase and Related Subgroup Enzymes: Implications for Catalysis.
Biochemistry
January 2025
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Enzymes of the enolase superfamily (ENS) are mechanistically diverse, yet share a common partial reaction, i.e., the metal-assisted, Bro̷nsted base-catalyzed abstraction of the α-proton from a carboxylate substrate to form an enol(ate) intermediate.
View Article and Find Full Text PDFRetrospective evaluation of acid-base imbalances, clinicopathologic alterations, and prognostic factors in hospitalized calves with Eimeria-associated diarrhea.
Front Vet Sci
January 2025
Clinic for Ruminants with Ambulatory and Herd Health Services, Center for Clinical Veterinary Medicine, LMU Munich, Munich, Germany.
Introduction: After the neonatal period Eimeriosis is one of the most common causes of large intestinal diarrhea in calves. In contrast to neonatal calves with diarrhea, there are very few reports about the clinicopathological alterations in affected animals, which are mainly based on experimental data. The aim of the present study was therefore to characterize acid-base and related clinicopathologic alterations in calves with Eimeria-associated diarrhea and to identify variables associated with in-hospital mortality.
View Article and Find Full Text PDFAssociation between base excess and mortality in septic older adults.
Geriatr Gerontol Int
January 2025
Department of Anesthesiology, Hekou District People's Hospital, Dongying City, China.
Aim: Septic older adults represent a vulnerable population with high mortality rates. Base excess (BE), an indicator of acid-base status, may serve as a prognostic marker in sepsis. This study aimed to investigate the association between BE and mortality in septic older adults.
View Article and Find Full Text PDFEnhanced antibacterial and antibiofilm activities of quaternized ultra-high deacetylated chitosan against multidrug-resistant bacteria.
Int J Biol Macromol
January 2025
Institute of Hepatobiliary Diseases, Transplant Center, Zhongnan Hospital, Hubei Engineering Center of Natural Polymers-based Medical Materials, Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China. Electronic address:
Multidrug-resistant (MDR) bacterial infections pose a severe threat to global public health and present significant challenges in the treatment of bacterial keratitis. The escalation of antimicrobial resistance (AMR) underscores the urgent need for alternative therapeutic strategies. In this study, we report the homogeneous synthesis of quaternized ultra-highly deacetylated chitosan (QUDCS) using a sequential acid-base combination approach.
View Article and Find Full Text PDFRetrospective evaluation of acid-base analysis in dogs and cats with diabetic ketosis (2017-2021): 96 cases.
J Vet Emerg Crit Care (San Antonio)
January 2025
Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Objective: To describe the acid-base balance of diabetic animals with ketosis and to identify underlying mechanisms of acid-base changes using semiquantitative analysis.
Design: Retrospective study.
Setting: University teaching hospital.
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