AI Article Synopsis
- Natural killer (NK) cell neoplasms are a diverse group of diseases that include various types of leukemias and lymphomas as classified by the WHO in 2008.
- These diseases remain difficult to distinguish from myeloid and T-cell neoplasms, highlighting some complexities in their classification, particularly for known entities like extranodal NK/T-cell lymphoma.
- The article provides an overview of the current understanding of NK cell biology and the pathology of NK neoplasms based on the WHO classification system.
Article Abstract
Natural killer (NK) cell neoplasm is a heterogeneous disease group. In the latest World Health Organization (WHO) classification of tumours of hematopoietic and lymphoid tissues (2008), disease entities considered as NK-cell derivation include NK-lymphoblastic leukemia/lymphoma, chronic lymphoproliferative disorders of NK cells, aggressive NK-cell leukemia, and extranodal NK-cell lymphoma, nasal-type. Despite recent advances in NK-cell research, which have expanded our understanding of the biology of NK-cell neoplasm, it cannot yet be sharply delineated from myeloid neoplasms and T-cell neoplasms even in some "well-known" entity, such as extranodal NK/T-cell lymphoma. This review describes current knowledge of the biology of NK cells and pathology of NK neoplasms as classified in the 2008 WHO classification of tumours of hematopoietic and lymphoid tissues.
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| http://dx.doi.org/10.1007/s12185-010-0738-y | DOI Listing |
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