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A Case of Anti-OJ Antibody-positive Antisynthetase Myopathy Diagnosed after Pulmonary Embolization.
Intern Med
November 2024
Department of Respiratory Internal Medicine, Onomichi General Hospital, Japan.
Idiopathic inflammatory myopathies, such as dermatomyositis, are implicated as possible risk factors for venous thromboembolism. We herein report the first known case of a 50-year-old woman who presented to our hospital with a fever, chest pain, and elevated creatine kinase levels and was ultimately diagnosed with pulmonary embolism and anti-OJ antibody-positive antisynthetase myopathy. Dermatomyositis may increase the risk of venous thromboembolism, including pulmonary embolism.
View Article and Find Full Text PDFComparison of Lineblot and Immunoprecipitation Methods in the Detection of Myositis-Specific and Myositis-Associated Antibodies in Patients with Idiopathic Inflammatory Myopathies: Consistency with Clinical Diagnoses.
Diagnostics (Basel)
September 2024
Rheumatology and Clinical Immunology Unit, ERN ReCONNET Centre, ASST Spedali Civili, Piazzale Spedali Civili, 1, 25124 Brescia, Italy.
Article Synopsis
- * A total of 69 patients were analyzed, showing high concordance for certain antibodies (like anti-Ku and anti-PM/Scl) and moderate agreement for others (like anti-Jo1 and anti-Mi-2), while some antibodies could only be detected by one method.
- * The results suggest that LB may be more sensitive for detecting multiple MSAs and specific antibodies, while IP performs well for dermatomyositis-associated MSAs
Prevalence and Clinical Implications of Autoantibodies in Juvenile Dermatomyositis: A Single-Center Experience From India.
J Clin Rheumatol
October 2024
Department of Pediatrics.
Article Synopsis
- The study investigated the presence of myositis-specific and myositis-associated autoantibodies (MSAs/MAAs) in a group of Indian children with juvenile dermatomyositis (JDM) and how these antibodies relate to clinical features and patient outcomes.
- A total of 43 children were assessed, with 81.4% testing positive for at least one type of autoantibody; the most common were anti-NXP2, anti-TIF1γ, and anti-MDA-5.
- While many patients showed positive responses to treatment, the study found no clear link between the specific autoantibody profiles and the successful achievement of complete clinical responses or remission.
Muscle pathology of antisynthetase syndrome according to antibody subtypes.
Brain Pathol
July 2023
Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Tokyo, Japan.
Identification of antisynthetase syndrome (ASS) could be challenging due to inaccessibility and technical difficulty of the serology test for the less common non-Jo-1 antibodies. This study aimed to describe ASS antibody-specific myopathology and evaluate the diagnostic utility of myofiber HLA-DR expression. We reviewed 212 ASS muscle biopsies and compared myopathologic features among subtypes.
View Article and Find Full Text PDFOverlap syndrome involving anti-OJ antibody-positive polymyositis, systemic lupus erythematosus and Sjögren's syndrome: A case report and literature review.
Mod Rheumatol Case Rep
June 2023
Department of Hematology, Rheumatology, and Infectious Diseases, Kumamoto University, Kumamoto, Japan.
Anti-OJ antibody is relatively rarely detected in patients with the anti-synthetase syndrome, which is polymyositis (PM)/dermatomyositis (DM) with anti-aminoacyl transfer ribonucleic acid (RNA) synthetase antibodies. There have been few case reports of anti-OJ antibody-positive PM/DM complicated by other connective tissue disorders. Herein, we report the case of a 33-year-old woman who was admitted to our hospital with fever, muscle weakness, and dyspnoea on exertion.
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