AI Article Synopsis
- - The study presents a microwave method to convert bromides into sodium sulfonates, which can be further transformed into sulfonyl chlorides.
- - This new microwave approach significantly enhances reaction yields and reduces reaction times compared to traditional methods.
- - The sulfonyl chlorides produced are used to create sulfonyl fluorides, which are effective inhibitors of the enzyme fatty acid amide hydrolase.
Article Abstract
We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sulfonyl chlorides serve as precursors for the respective sulfonyl fluorides that are potent inhibitors of the fatty acid amide hydrolase.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994267 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2009.09.167 | DOI Listing |
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