Purpose: The purpose of this meta-analysis was to investigate whether locus of control (LOC) for internal LOC, powerful others, or chance is correlated with how well people control diabetes (measured by H1C).
Methods: The literature search included Medline, CINAHL, PsychINFO, PsychArticles, Health Source, Academic Search Elite, EMBASE, Current Contents, and BIOsis databases, which yielded 296 articles. Selection criteria for inclusion were adult participants with diabetes mellitus, use of glycosylated hemoglobin (H1C) as a measure of glycemic control, measurement of a locus-of control scale, and a Pearson correlation (r) value. Seventeen articles met all inclusion criteria. The R package "metacor," was used to perform a random effects meta-analysis and estimate correlation coefficients between the 3 LOC measurements and H1C.
Results: The strength of subjects ascribing an internal LOC (across 13 studies) was uncorrelated with H1C (r = -0.0099; 95% confidence interval [CI], -0.1092, 0.0893). A LOC ascribed to powerful others LOC (across 9 studies) was similarly uncorrelated with H1C (r = 0.0928; 95% CI, -0.0136, 0.1993). Ascribing LOC to chance (across 9 studies) was also uncorrelated with H1C (r = 0.0926; 95% CI, -0.0398, 0.2250).
Conclusions: This meta-analysis of 17 studies found no correlation between the control of diabetes and LOC. At best, there may be a weak correlation between powerful others and chance LOC with the metabolic control of diabetes. The use of LOC as a means of designing diabetes care can be discarded as this random effects meta-analysis found no significant correlation with effectiveness of diabetes control in adult patients.
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http://dx.doi.org/10.1177/0145721710388425 | DOI Listing |
FEBS J
January 2025
Department of Drug Design and Pharmacology, University of Copenhagen, Denmark.
The glucagon-like peptide-1 receptor (GLP-1R) plays an important role in regulating insulin secretion and reducing body weight, making it a prominent target in the treatment of type 2 diabetes and obesity. Extensive research on GLP-1R signaling has provided insights into the connection between receptor function and physiological outcomes, such as the correlation between Gs signaling and insulin secretion, yet the exact mechanisms regulating signaling remain unclear. Here, we explore the internalization pathway of GLP-1R, which is crucial for controlling insulin release and maintaining pancreatic beta-cell function.
View Article and Find Full Text PDFDrugs Aging
January 2025
Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
IgG4-related disease (IgG4-RD) is an immune-mediated disorder characterized by organ enlargement and dysfunction. The formation of tertiary lymphoid tissues (TLTs) in affected organs is crucial for understanding IgG4-RD, as T follicular helper (Tfh) 2 cells within TLTs drive IgG4+B cell differentiation, contributing to mass formation. Key cytokines IL-4 and IL-10, produced by Tfh2 cells, are essential for this process.
View Article and Find Full Text PDFDiabetologia
January 2025
Department of Public Health, University of Helsinki, Helsinki, Finland.
Aims/hypothesis: Eating disorders are over-represented in type 1 diabetes and are associated with an increased risk of complications, but it is unclear whether type 1 diabetes affects the treatment of eating disorders. We assessed incidence and treatment of eating disorders in a nationwide sample of individuals with type 1 diabetes and diabetes-free control individuals.
Methods: Our study comprised 11,055 individuals aged <30 who had been diagnosed with type 1 diabetes in 1998-2010, and 11,055 diabetes-free control individuals matched for age, sex and hospital district.
Sci Rep
January 2025
Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Republic of Korea.
To determine longitudinal changes in the peripapillary retinal nerve fiber layer (pRNFL) thickness in type 2 diabetes mellitus (T2DM) patients with hypertension (HTN). Participants were divided into three groups: normal controls (Group 1), patients with T2DM (Group 2), and patients with both T2DM and HTN (Group 3). Following the initial examination, patients underwent three additional examinations at 1-year intervals.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Epidemiology, School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen, China.
While recent studies have indicated a potential link between incense burning and respiratory diseases, there is a lack of data specifically focused on diabetic patients. To explore the relationship between indoor incense burning and impaired lung function among Chinese individuals with diabetes, a comprehensive cross-sectional study was undertaken, enrolling 431 adults diagnosed with diabetes. Information on incense burning and characteristics was collected using a structured questionnaire.
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