Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.acthis.2010.10.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adiponectin Signaling Modulates Fat Taste Responsiveness in Mice.
Nutrients
October 2024
Department of Internal Medicine, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.
Background/objectives: Adiponectin, the most abundant peptide hormone secreted by adipocytes, is a well-known homeostatic factor regulating lipid metabolism and insulin sensitivity. It has been shown that the adiponectin receptor agonist AdipoRon selectively enhances cellular responses to fatty acids in human taste cells, and adiponectin selectively increases taste behavioral responses to intralipid in mice. However, the molecular mechanism underlying the physiological effects of adiponectin on fat taste in mice remains unclear.
View Article and Find Full Text PDFFAHFA promotes intracellular calcium signaling via activating the fat taste receptor, CD36 and Src protein kinases in mice taste bud cells.
Biochim Biophys Acta Gen Subj
December 2024
Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, Tamilnadu 641046, India. Electronic address:
Two lipid sensors, CD36 and GPR120, are crucial for the orosensory detection of fat taste and for mediating fat preference. However, the mechanism by which endogenous lipid (FAHFA) binds to CD36 to initiate intracellular signaling remains unexplained. Hence, the primary objective of this study is to investigate the binding mechanism of FAHFA to CD36 and its role in isolated mouse taste bud cells (mTBCs).
View Article and Find Full Text PDF[Genetic variants in CD36: emerging role in oral fat perception and food preferences].
Nutr Hosp
December 2023
Instituto de Investigaciones en Comportamiento Alimentario y Nutrición. Universidad de Guadalajara.
CD36 is a receptor involved in physiologic, metabolic and pathologic processes. Due to its affinity for long-chain fatty acids, it has been postulated as a taste receptor of fatty taste. In this review, the emerging genetic evidence linking CD36 to oral fat perception is analyzed.
View Article and Find Full Text PDFAdiponectin Enhances Fatty Acid Signaling in Human Taste Cells by Increasing Surface Expression of CD36.
Int J Mol Sci
March 2023
Department of Internal Medicine, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.
Adiponectin, a key metabolic hormone, is secreted into the circulation by fat cells where it enhances insulin sensitivity and stimulates glucose and fatty acid metabolism. Adiponectin receptors are highly expressed in the taste system; however, their effects and mechanisms of action in the modulation of gustatory function remain unclear. We utilized an immortalized human fungiform taste cell line (HuFF) to investigate the effect of AdipoRon, an adiponectin receptor agonist, on fatty acid-induced calcium responses.
View Article and Find Full Text PDFNovel Fat Taste Receptor Agonists Curtail Progressive Weight Gain in Obese Male Mice.
Cell Mol Gastroenterol Hepatol
February 2023
NUTox, UMR UB/AgroSup/INSERM U1231, Lipides, Nutrition & Cancer, LABEX-LipStick, Université de Bourgogne-Franche Comté (UBFC), Dijon, France. Electronic address:
Background & Aims: The spontaneous preference for dietary lipids is principally regulated by 2 lingual fat taste receptors, CD36 and GPR120. Obese animals and most of human subjects exhibit low orosensory perception of dietary fat because of malfunctioning of these taste receptors. Our aim was to target the 2 fat taste receptors by newly synthesized high affinity fatty acid agonists to decrease fat-rich food intake and obesity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!