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New alternative approaches to stroke treatment: the blood cell-derived secretome shows promise in individuals with obesity.
Metab Brain Dis
December 2024
Biomedical Research Center of the Slovak Academy of Sciences, Institute of Neurobiology, Soltesovej 4-6, 040 01, Košice, Slovak Republic.
Ischaemic tolerance induced by remote ischaemic conditioning (RIC) has been extensively demonstrated in several preclinical models of cerebral ischaemia. However, animals with common stroke-related comorbidities do not benefit from the recent advances of RIC. Therefore, we investigated two alternative approaches for obese animals with stroke: (1) the efficacy of an additional round of the standard RIC protocol, and (2) the paracrine potential of the blood cell-derived secretome derived from RIC-induced healthy young rats.
View Article and Find Full Text PDFDexmedetomidine preconditioning attenuates ferroptosis in myocardial ischemia-reperfusion injury via α2 adrenergic receptor activation.
Heliyon
November 2024
Department of Anesthesiology, Qingdao Women and Children's Hospital, School of Medicine, Shandong University, Jinan, China.
Objective: Dexmedetomidine (Dex) is a potent agonist of the α2 adrenergic receptor that has been shown to possess sedative and hypnotic properties. Dex can protect against myocardial ischemia-reperfusion injury (MIRI) by inhibiting ferroptosis. However, these studies were based on Dex post-conditioning, and the role of α2 adrenergic receptors in this process is unclear.
View Article and Find Full Text PDFCardioprotection by Preconditioning with Intralipid Is Sustained in a Model of Endothelial Dysfunction for Isolated-Perfused Hearts.
Int J Mol Sci
October 2024
Department of Anesthesiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Endothelial dysfunction (ED) is closely associated with most cardiovascular diseases. Experimental models are needed to analyze the potential impact of ED on cardioprotection in constant pressure Langendorff systems (CPLS). One cardioprotective strategy against ischemia/reperfusion injury (I/RI) is conditioning with the lipid emulsion Intralipid (IL).
View Article and Find Full Text PDFDifferences in motor network reorganization between patients with good and poor upper extremity impairment outcomes after stroke.
Brain Imaging Behav
December 2024
Department of Rehabilitation Center, Fu Xing Hospital, Capital Medical University, 20#, Fu Xing Men Wai Street, Beijing, 100038, China.
Article Synopsis
- After a stroke, how the brain controls movement can change, which is important for recovery.
- This study looked at two groups of stroke patients: those who improved a lot and those who didn't, checking their movement abilities before, after rehab, and a year later.
- It found that brain activity patterns were different between the groups, with better recovery linked to certain brain connections, suggesting that how the brain adapts after a stroke can affect how well someone moves their arm later on.
Cardioprotective microRNAs (protectomiRs) in a pig model of acute myocardial infarction and cardioprotection by ischaemic conditioning: MiR-450a.
Br J Pharmacol
January 2025
Cardiometabolic and HUN-REN-SU System Pharmacology Research Group, Center for Pharmacology and Drug Research & Development, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
Article Synopsis
- The study investigates cardioprotective microRNAs (protectomiRs) in a pig model of acute myocardial infarction (AMI) to find potential therapeutic options for heart protection.
- Researchers analyzed changes in miRNA expression in cardiac tissues and validated candidates in lab models using rat and human heart cells.
- The findings highlight miR-450a as a significant protectomiR, linked to protection during ischemic conditions and having common pathways and targets across species, making it a strong candidate for future heart therapies.
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