AI Article Synopsis
- Research shows that major depressive disorder (MDD) affects autonomic control, specifically heart rate variability (HRV).
- In this study, researchers compared brain activity and HRV in medically healthy women with MDD and healthy controls while performing stressful tasks.
- The findings revealed differences in brain blood flow patterns and HRV correlations between the two groups, particularly in the orbital cortices, highlighting their roles in autonomic control and MDD's pathophysiology.
Article Abstract
Research indicates that major depressive disorder (MDD) is associated with alterations in autonomic control, particularly cardiac control as measured by heart rate variability (HRV). In this preliminary study, we investigated the neural correlates of autonomic control by measuring both HRV and associated brain activity during the performance of mildly stressful tasks. Medically healthy female subjects with MDD (N=10) and healthy controls (N=7) underwent H(2)(15)O-positron emission tomography (PET) and electrocardiographic ECG recording while performing a handgrip motor task and an n-back task. Indices of HRV were calculated and correlated with regional cerebral blood flow (rCBF). Differences in the rCBF and HRV correlations between depressed and healthy subjects were evident in both the medial and lateral orbital cortices. In addition, these areas appeared to be involved in different facets of autonomic control with regard to sympathetic or parasympathetic dominance of cardiac control. These results are consistent with the known roles of networks within the orbital cortex in both autonomic control and the pathophysiology of MDD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032348 | PMC |
| http://dx.doi.org/10.1016/j.pscychresns.2010.08.013 | DOI Listing |
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