AI Article Synopsis
- Breast cancer is the most common cancer among women in western countries, accounting for 22% of all female cancers globally, with over 370,000 deaths each year.
- Post-operative radiation therapy significantly reduces the risk of local recurrence and specific mortality by targeting areas affected by cancer, particularly in patients with axillary nodal involvement.
- The article aims to outline the epidemiology, anatomy, and treatment guidelines for breast cancers with axillary nodal involvement, supported by a case report for illustration.
Article Abstract
Breast cancer is the most frequent cancer of women in western countries. There are one million new cases per year in the world which represents 22% of all female cancers, and more than 370,000 deaths due to breast cancer per year (14% of cancer mortality). More than half of breast cancers are associated with axillary nodal involvement. Post-operative radiation therapy (XRT) is a crucial part of locoregional treatment in axillary nodal involvement breast cancer owing to a 15-years risk reduction of locoregional recurrence of 70% and to a 5.4% risk reduction of specific mortality. In 3D-conformal irradiation in such breast cancers, target volumes are chest wall when mastectomy was performed or breast and boost of tumor bed in case of breast conservative surgery, and supra-clavicular and/or axillary and/or internal mammary node areas. The main organs at risk are ipsilateral lung, heart and brachial plexus. The aim of this article is to describe epidemiologic, radio anatomic and prognostic features of axillary nodal involvement breast cancer and to propose guidelines for 3D-conformal treatment planning in locally advanced breast cancers. This review is illustrated by a case report.
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| http://dx.doi.org/10.1016/S1278-3218(10)70017-2 | DOI Listing |
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