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Synthesis of Novel Chromene Derivatives Bearing Hydrazide/Thiazol/Oxazol/Oxime Moieties as Potential Antifungal Agents.
J Agric Food Chem
December 2024
College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550004, People's Republic of China.
Four series of novel hydrazide/thiazol/oxazol/oxime ester hybrids of chromene derivatives were designed and synthesized to explore natural-product-based fungicide candidates. Preliminary antifungal activity assay results demonstrated that hydrazide-chromene and thiazol-chromene derivatives exhibited excellent and broad-spectrum inhibitory activity against ten phytopathogenic fungi. Among them, six compounds , , , , , and displayed the most remarkable antifungal effects.
View Article and Find Full Text PDFPreparation of Multifunctional Nano-Protectants for High-Efficiency Green Control of Anthracnose.
Adv Sci (Weinh)
December 2024
Frontiers Science Center for Molecular Design Breeding, Department of Plant Biosecurity, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
Nanomaterials cannot only act as active ingredients (AIs), but also adjuvants to encapsulate or attach AIs to improve their fungicidal activity. Herein, a hydrophilic and lipophilic diblock polymer (HLDP) is designed and synthesized to prepare a series of HLDP nano-protectants to explore the best HLDP nano-protectant for anthracnose management. These results demonstrate that the HLDP-CS nano-protectant displays the best control effects on mango anthracnose via the direct pathogen inhibition and amplified plant immune responses.
View Article and Find Full Text PDFBackground: β-sitosterol is a natural plant steroidal compound with anti-cancer properties against various tumors. This work attempts to explore the inhibitory effect of β-sitosterol on the progression of lung adenocarcinoma (LUAD) and further analyze its targets.
Methods: In this work, we applied network pharmacology to obtain the components and targets of Ganoderma spore powder.
Effects of carbon dioxide on germination of Clostridium botulinum spores.
Int J Food Microbiol
January 2025
ACTIA, 149, rue de Bercy, 75595 Paris Cedex 12, France. Electronic address:
Clostridium botulinum is a Gram -positive, strict anaerobic, rod -shaped, spore -forming, SOD -positive and catalase -negative bacterium. Its antioxidant defenses are not suited to chronic oxidative stress. H₂O₂ and reactive oxygen species have deleterious effects on C.
View Article and Find Full Text PDFManagement of Disseminated Rhinosporidiosis: Experience From a Single Tertiary Institution.
Turk Arch Otorhinolaryngol
October 2024
Department of Otorhinolaryngology, Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER), Pondicherry, India.
Objective: This study aims to present a series of patients with disseminated rhinosporidosis with diagnostic and therapeutic features.
Methods: A retrospective study was conducted in a tertiary health care centre in South India from 2007 to 2020 with disseminated rhinosporidiosis. Twelve patients with multiple sites of involvement like the nose, nasopharynx, oropharynx, larynx, lacrimal sac and skin were included in the study.
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