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Biologic Augmented Scaffold-based cartilage repair: Addressing Complications and Enhancing Outcomes.
J Clin Orthop Trauma
March 2025
Department of Orthopaedic Surgery, Sengkang General Hospital, Singapore.
Cartilage repair remains a significant challenge due to the tissue's limited innate regenerative capacity. Despite advances in techniques such as microfracture, autologous chondrocyte implantation (ACI), and osteochondral grafting, long-term outcomes are often compromised by complications, including suboptimal tissue integration, graft resorption, and mechanical instability. Recently, biologically augmented scaffold-based cartilage repair has emerged as a promising approach for full-thickness osteochondral lesions.
View Article and Find Full Text PDFSuppressing Cation Interdiffusion at CeO/ZrO Heterointerfaces via Dopant Segregation.
ACS Appl Mater Interfaces
January 2025
Hydrogen Fuel Cell Laboratory, Korea Institute of Energy Research (KIER), 152 Gajeong-ro, Yuseong-gu, Daejeon 34129, Korea.
Cation interdiffusion as a result of a chemical-potential gradient occurring at heterointerfaces is often regarded as an unfavorable side reaction and is typically suppressed through the use of a diffusion barrier layer. In this study, we propose a straightforward method for suppressing interdiffusion that involves the creation of nanometer-thick diffusion barrier layers by means of dopant segregation. Using the CeO/ZrO heterointerface in this study, we demonstrate that a Sc acceptor dopant tends to accumulate at the heterointerface during the sintering process, especially at the edge of the CeO grain boundary, thereby effectively suppressing Ce-Zr interdiffusion.
View Article and Find Full Text PDFBackground: To evaluate the associations between anatomical changes and visual outcomes after membrane peeling in eyes with different stages of idiopathic epiretinal membrane (iERM) using optical coherence tomography angiography (OCTA).
Methods: All iERM eyes were graded into four stages based on the presence of ectopic inner foveal layers (EIFL) and underwent 23-gauge vitrectomy combined with ERM and internal limiting membrane (ILM) peeling, while their fellow eyes were treated as the control group. OCTA was used to measure retinal thickness(RT), foveal avascular zone (FAZ)-related parameters and superficial and deep capillary plexus (SCP and DCP) layers using 6 × 6 mm scans before, 1 month and 3 months after surgery.
Corneal Perforation Associated with Pembrolizumab - A Case Report with Literature Review.
Ocul Immunol Inflamm
January 2025
Universiti Malaya Eye Research Centre (UMERC), Department of Ophthalmology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Purpose: To shed light on one of the ocular adverse effects related to pembrolizumab.
Method: Case report and literature review.
Result: A 53-year-old gentleman with underlying Stage III B renal cell carcinoma with lung metastasis and gout presented in June 2021 with bilateral red eyes following Coronavirus disease (COVID-19) vaccination.
Multilayer Composite Electrodes for Simultaneously Improved Mechanical and Electrochemical Performance.
ACS Appl Mater Interfaces
January 2025
The Harold & Inge Marcus Department of Industrial & Manufacturing Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Structural batteries offer a transformative approach to integrate energy storage directly into the frameworks of electric vehicles and aircrafts, enabling multifunctional construction. This study presents a nacre-inspired multilayer composite electrode fabricated via the cold sintering process (CSP), achieving a balance of enhanced electrochemical performance and mechanical robustness. The composite electrode combines active electrode materials with a ductile conducting polymer-carbon-mixture phase in a layered architecture.
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