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DNA damage response and repair gene mutations predict clinical outcomes in biliary tract cancer.
Cancer
February 2025
Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Background: This study aims to explore the genetic characteristics of biliary tract cancer (BTC), with a particular focus on the impact of DNA damage response and repair (DDR) genes on clinical outcomes.
Methods: A total of 180 patients with BTC and next-generation sequencing data were retrospectively analyzed. Clinical outcomes were compared between DDR-positive and DDR-negative groups.
Management of advanced gallbladder adenocarcinoma: A case report and review of treatment strategies.
Int J Surg Case Rep
January 2025
Department of Surgery, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; University of California, Center for Global Surgery, Sacramento, CA, USA.
Introduction And Importance: Gallbladder cancer (GBC) is a rare but aggressive malignancy, accounting for most biliary tract cancers. It typically presents at an advanced stage, leading to a poor prognosis, with a mean survival of six months and a five-year survival rate of 17.6 %.
View Article and Find Full Text PDF"Biliary-cast syndrome" ("BCS") is most often encountered in clinical practice as a complication after liver transplantation, there are also described cases of biliary-cast syndrome in patients who did not undergo liver transplantation, isolated cases of "BCS" developing in patients with acute pancreatitis, choledocholithiasis are described in literature. Ischemic damage to bile duct epithelium with development of cholestasis and retrograde biliary tract infection are considered as the main etiological factors. This work presents a clinical case of "Biliary-cast syndrome" in a patient with acute biliary pancreatitis and pulmonary embolism.
View Article and Find Full Text PDFSmall common bile duct - the risk factor for post-ERCP pancreatitis in patients with choledocholithiasis.
Wiad Lek
January 2025
SALISBURY NHS FOUNDATION TRUST, SALISBURY, UNITED KINGDOM.
Objective: Aim: To investigate the risk factors for PEP in patients with choledocholithiasis.
Patients And Methods: Materials and Methods: We have retrospectively analyzed 253 cases with choledocholithiasis that underwent ERCP. The primary endpoint was the occurrence of PEP.
Diagnosis of rare signet-ring cell carcinoma of bile duct by endoscopic ultrasonography combined with a peroral direct cholangioscopy biopsy.
Rev Esp Enferm Dig
January 2025
Biliopancreatic Endoscopic Surgery, The Second Hospital of Hebei Medical University, .
Biliary signet-ring cell carcinoma is a rare malignant tumor of the biliary tract. signet-ring cell carcinoma often occurs in the gastrointestinal tract. In this case, we can intuitively see the location, shape and scope of the tumor through endoscopic ultrasonography (EUS) combined with a peroral direct choledochoscope.
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