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Sodium Thiosulfate: An Innovative Multi-Target Repurposed Treatment Strategy for Late-Onset Alzheimer's Disease.
Pharmaceuticals (Basel)
December 2024
Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Late-onset Alzheimer's disease (LOAD) is a chronic, multifactorial, and progressive neurodegenerative disease that associates with aging and is highly prevalent in our older population (≥65 years of age). This hypothesis generating this narrative review will examine the important role for the use of sodium thiosulfate (STS) as a possible multi-targeting treatment option for LOAD. Sulfur is widely available in our environment and is responsible for forming organosulfur compounds that are known to be associated with a wide range of biological activities in the brain.
View Article and Find Full Text PDFWe present a case of asymptomatic non-union of distal clavicle fracture in an older adult who experienced late-onset skin dehiscence and a secondarily open fracture. We adopted a simplified surgical approach involving resection of the protruding medial clavicular fragment instead of fixation of the non-union. This approach led to the rapid healing of soft tissues while maintaining an ulcer-free status and adequate shoulder function at the one-year follow-up.
View Article and Find Full Text PDFNivolumab-Induced Immune Mediated Colitis Localized to the Distal Colon: Seven Years Into Therapy.
Cureus
October 2024
Pathology, Heartland Pathology Laboratories, Wichita, USA.
Nivolumab targets programmed cell death protein 1 (PD-1) and is used in cancer treatment by increasing the immune response. It has rarely been associated with immune-mediated colitis (IMC). We present a 66-year-old man with metastatic lung adenocarcinoma, treated with nivolumab for seven years, who developed tenesmus and mucoid bloody diarrhea.
View Article and Find Full Text PDFThe Pouch Corner: Perianal Fistulas and Ileal Pouches: Examining Fistulas Before and After Pouch Creation.
Inflamm Bowel Dis
January 2025
Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
The association between primary ovarian insufficiency and increased multimorbidity in a large prospective cohort (Canadian Longitudinal Study on Aging).
Fertil Steril
August 2024
Department of Obstetrics and Gynecology, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada; McMaster Institute for Research on Aging, Hamilton, Ontario, Canada; The Research Institute, St. Joseph's Healthcare, Hamilton, Ontario, Canada. Electronic address:
Objective: To describe the prevalence of multimorbidity among individuals with primary ovarian insufficiency (POI) and early menopause compared with those with the average age of menopause.
Design: Prospective cohort.
Setting: Outpatient communities across ten provinces across Canada, available from the Canadian Longitudinal Study on Aging.
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