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ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment.
J Crohns Colitis
October 2024
Department of Surgery and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
This article is the second in a series of two publications on the European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn's disease. The first article covers medical management; the present article addresses surgical management, including preoperative aspects and drug management before surgery. It also provides technical advice for a variety of common clinical situations.
View Article and Find Full Text PDFSafety and efficacy of autologous haematopoietic stem-cell transplantation with low-dose cyclophosphamide mobilisation and reduced intensity conditioning versus standard of care in refractory Crohn's disease (ASTIClite): an open-label, multicentre, randomised controlled trial.
Lancet Gastroenterol Hepatol
April 2024
Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK; Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Background: A previous controlled trial of autologous haematopoietic stem-cell transplantation (HSCT) in patients with refractory Crohn's disease did not meet its primary endpoint and reported high toxicity. We aimed to assess the safety and efficacy of HSCT with an immune-ablative regimen of reduced intensity versus standard of care in this patient population.
Methods: This open-label, multicentre, randomised controlled trial was conducted in nine National Health Service hospital trusts across the UK.
Determining the optimal treatment target in patients with ulcerative colitis: rationale, design, protocol and interim analysis for the randomised controlled VERDICT trial.
BMJ Open Gastroenterol
February 2024
Department of Medicine, Division of Gastroenterology; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.
Article Synopsis
- * It involves 660 patients assigned to three different treatment approaches focusing on symptom relief, endoscopic healing, or both along with histologic healing, using the medication vedolizumab.
- * The primary goal is to see how long patients can maintain remission without complications, with results to be published in scientific forums following ethical approval.
Evaluation of CO removal rate of ECCOR for a renal replacement therapy platform in an experimental setting.
Artif Organs
June 2024
Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Background: A critical parameter of extracorporeal CO removal (ECCOR) applications is the CO removal rate (VCO). Low-flow venovenous extracorporeal support with large-size membrane lung remains undefined. This study aimed to evaluate the VCO of a low-flow ECCOR with large-size membrane lung using a renal replacement therapy platform in an experimental animal model.
View Article and Find Full Text PDFThe inflammatory bowel disease care manager: Italian state of the art.
Ann Gastroenterol
December 2023
UOS Malattie Infiammatorie Croniche Intestinali, Centro di Malattie dell'Apparato Digerente (CEMAD), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Roma (Daniele Napolitano, Federica Di Vincenzo, Elisa Schiavoni, Daniela Pugliese, Franco Scaldaferri).
Background: In the inflammatory bowel disease (IBD) multidisciplinary team, a key figure is the IBD care manager, usually an independent practice nurse, responsible for evidence-based assessment, care planning, treatment evaluation, and provision of practical information, health education, and emotional support to patients. The objective of this study was to evaluate the profile of this figure in Italy.
Methods: A team of experienced nurses created a questionnaire based on the Second N-ECCO declaration, which was administered to nurses who worked in an IBD unit for a period of at least 3 years.
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