Nonantibiotic therapy for multidrug-resistant Pseudomonas aeruginosa in a patient with chronic burn wounds.

The authors report a special case of nonantibiotic therapy in a adolescent boy with chronically infected wounds induced by inappropriate use of antibiotics. The result of microbial cultures of the secretions on the wounds indicated that the infection of multidrug-resistant Pseudomonas aeruginosa was resistant to aminoglycoside and cephalosporin but sensitive to carbapenem and quinolones. We formulated a management strategy including daily hydrotherapy, thermal radiation therapy, balanced fluid and electrolytes and intermittent transfusion of blood products, but antibiotics were not used. Twenty-four days after his hospitalization, an autologous split-meshed skin grafting was successfully performed. He was followed up for 6 months after discharge; both lower extremities had an excellent functional recovery. The therapy introduced in this report may be beneficial for chronic infected wounds.