Background: Several studies suggest that the detection of nucleated red blood cells (NRBCs) in hospitalized patients indicates an increased risk of mortality. This study evaluates the impact of low arterial oxygen partial tension (pO₂) on NRBC appearance and prognosis in NRBC positive patients.
Methods: NRBCs in blood, arterial blood gases, and other laboratory parameters were monitored daily in 234 surgical intensive care patients. pO₂ was assessed in relation to mortality and the detection of NRBCs.
Results: NRBCs were found in 67 patients (28.6%). Mortality was significantly higher in NRBC positive patients (41.8%, 28/67) than in those that were NRBC negative (3.0%, 5/167). Multivariate logistic regression showed an increased mortality in NRBC positive patients (odds ratio 5.79; 95% confidence interval (CI) 1.07-31.33, p < 0.05). NRBC positive patients showed significantly lower pO₂ levels during intensive care treatment than NRBC negative patients. Prior to the initial detection of NRBCs in the peripheral blood, pO₂ levels were significantly lower in patients who died than in surviving patients. After the first appearance of NRBCs, no significant difference in pO₂ between these groups was found.
Conclusions: The detection of NRBCs is of prognostic significance concerning patient mortality. In NRBC positive patients, hypoxemia occurs more frequently. Low-levels of pO₂ seem to precede the appearance of NRBCs, especially in those patients with high risk of mortality.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1515/CCLM.2011.041 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogs.
J Vet Intern Med
December 2024
College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
Background: Nucleated red blood cells (nRBCs) are increased by disease processes and hematopoietic stress.
Objectives: To evaluate the utility of nRBCs as a marker of disease severity and prognosis in dogs with systemic inflammatory response syndrome (SIRS).
Animals: Sixty-two client-owned dogs met the criteria of SIRS without anemia.
Pseudo-NRBC in the Mindray BC-6800Plus analyzer: A clue for diagnostic anticipation of fungemia. Experimental and preliminary clinical reports.
Int J Lab Hematol
October 2024
Department of Clinical Laboratory, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, China.
Introduction: Candidemia can be a significant cause of death in immunosuppressed or debilitated patients particularly. Abnormalities of the instrumental cytograms of some hematological analyzers, such as Mindray BC-6800Plus, can be related to circulating Candida. We studied the possible diagnostic usefulness of this information.
View Article and Find Full Text PDFNucleated Red Blood Cell Counts Differentiate Cardiac from Respiratory Causes of Cyanosis at Birth.
Pediatr Cardiol
March 2024
Division of Cardiology, Central Michigan University College of Medicine, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA.
Tissue hypoxia increases erythropoietin production and release of immature erythrocytes that can be measured using nucleated red blood cell counts (nRBC). We hypothesized that hypoxia due to congenital heart disease (CHD) is chronic and is better tolerated than hypoxia due to respiratory disease (RD), which is an acute stress in newborns leading to higher nRBC. This study assesses the utility of nRBC as a marker to differentiate hypoxia due to CHD vs RD in term neonates.
View Article and Find Full Text PDFNucleated red blood cells are a late biomarker in predicting intensive care unit mortality in patients with COVID-19 acute respiratory distress syndrome: an observational cohort study.
Front Immunol
February 2024
Department of Internal Medicine II, Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardiopulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.
Background: Nucleated red blood cells (nRBC) are precursor cells of the erythropoiesis that are absent from the peripheral blood under physiological conditions. Their presence is associated with adverse outcomes in critically ill patients. This study aimed to evaluate the predictive value of nRBC on mortality in intensive care unit (ICU) patients with COVID-19 acute respiratory distress syndrome (ARDS).
View Article and Find Full Text PDFNucleated red blood cells as a novel biomarker in the diagnosis and prediction of sepsis severity in children.
Front Cell Infect Microbiol
December 2023
Department of Emergency, Children's Hospital of Chongqing Medical University, Chongqing, China.
Introduction: Sepsis is a vitally serious disease leading to high mortality. Nucleated red blood cells (NRBCs) are present in some noninfectious diseases, but the relationship between NRBCs and sepsis in children remains unknown. The purpose of this study was to compare the clinical characteristics and outcomes of sepsis with positive NRBCs and negative NRBCs in children, and to further explore whether the count of NRBCs has a relationship with the severity of sepsis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!