Objective: The purpose of this study was to describe the demographic and clinical variables of the conditionally released forensic patient population in New South Wales.
Method: Data were gathered from 74 conditionally released forensic patients.
Results: Of this population, 37% had committed homicides and 50% had committed serious violent offences (attempted murder, grievous bodily harm or robbery). Approximately two-thirds had their first admission to a psychiatric hospital before the age of 30. The majority (83%) of patients were diagnosed with schizophrenia and 55% had a history of substance use disorders; 24% were deemed to have been intoxicated at the time of the offence.
Conclusions: Conditionally released forensic patients in NSW show similar characteristics to those in other jurisdictions. Areas identified for further evaluation are comorbid substance use and rehabilitation, longer term outcomes and the under representation of indigenous persons.
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http://dx.doi.org/10.3109/10398562.2010.499434 | DOI Listing |
Angew Chem Int Ed Engl
December 2024
Laboratory of Medicinal Chemical Biology, Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, College of Pharmaceutical Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China.
Bioorthogonalized light-responsive click-and-uncage platform has enabled precise cell surface engineering and timed payload release, but most of such photoactivatable prodrugs have "always-on" photoactivity leading to the dark toxicity. On the other hand, the conditionally activatable photocage is limited to the application of fluorogenic probe/photosensitizer liberation. Herein, we devise a conditionally activatable theranostic platform based on the tetrazine (Tz)-boron-dipyrromethene (BODIPY) construct, in which tetrazine serves as a quencher motif to disable both the fluorescence and photoresponsivity of BODIPY.
View Article and Find Full Text PDFJ Mol Cell Cardiol Plus
December 2024
Department of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic arrhythmic syndrome caused by mutations in the calcium (Ca) release channel ryanodine receptor (RyR2) and its accessory proteins. These mutations make the channel leaky, resulting in Ca-dependent arrhythmias. Besides arrhythmias, CPVT hearts typically lack structural cardiac remodeling, a characteristic often observed in other cardiac conditions (heart failure, prediabetes) also marked by RyR2 leak.
View Article and Find Full Text PDFACS Synth Biol
December 2024
Beijing National Laboratory for Molecular Sciences (BNLMS), Chinese Academy of Sciences Key Laboratory of Molecular Recognition and Function, Chinese Academy of Sciences Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
CRISPR/Cas systems, particularly CRISPR/Cas12a, have revolutionized nucleic acid detection due to their exceptional specificity and sensitivity. However, CRISPR/Cas12a's cleavage activity can interfere with amplification processes, such as reverse transcription (RT) and isothermal amplification (e.g.
View Article and Find Full Text PDFCell Commun Signal
December 2024
CNR Institute of Biochemistry and Cell Biology, Monterotondo, Rome, 00015, Italy.
Connexins (Cxs) are fundamental in cell-cell communication, functioning as gap junction channels (GJCs) that facilitate solute exchange between adjacent cells and as hemichannels (HCs) that mediate solute exchange between the cytoplasm and the extracellular environment. Mutations in the GJB1 gene, which encodes Cx32, lead to X-linked Charcot-Marie-Tooth type 1 (CMTX1), a rare hereditary demyelinating disorder of the peripheral nervous system (PNS) without an effective cure or treatment. In Schwann cells, Cx32 HCs are thought to play a role in myelination by enhancing intracellular and intercellular Ca signaling, which is crucial for proper PNS myelination.
View Article and Find Full Text PDFJ Virol
December 2024
Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Unlabelled: Herpesviruses carry an assortment of proteins in the interstitial space between the capsid and membrane envelope, collectively referred to as the tegument. Upon virion fusion with a cell, envelope integrity is disrupted, and many tegument constituents disperse into the cytosol to carry out individual effector functions, while others direct transport of the capsid to the nucleus. To gain insight into the tegument dynamics that occur with disruption of envelope integrity, we used a combination of single-particle fluorescence and biochemical approaches that leveraged the previously established use of n-ethylmaleimide to inhibit virion dynamics.
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