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Rationale and Design of the Personalized Therapy Study: Evaluating Real-World Performance of Two Automated Defibrillation Therapy Algorithms.
J Card Fail
December 2024
The Heart and Vascular Center at The Christ Hospital, Cincinnati, OH, USA. Electronic address:
Background: Barriers to maximizing patient benefit with implantable defibrillation devices include limited ability to tailor antitachycardia pacing (ATP) therapy in real-time and identify patients at risk of heart failure (HF) events early on. The Personalized Therapy study aims to evaluate the performance of two algorithms, intrinsic ATP (iATP) and TriageHF, to address these barriers in routine clinical practice.
Methods And Results: The Personalized Therapy Study was designed as a prospective, multicenter, post-market registry study expected to enroll approximately 2,200 patients meeting the following criteria: (1) implanted with a study-eligible device regardless of procedure type; (2) Medtronic CareLink® Network enrolled; (3) TriageHF enabled within CareLink and High Risk Alert notifications turned ON; and (4) iATP enabled.
Challenges in the Development and Evaluation of Pediatric Heart Valve Technologies.
Ann Thorac Surg
December 2024
Georgia Institute of Technology and Emory University, Atlanta, GA. Electronic address:
Background: In October 2022, the Heart Valve Collaboratory and Food and Drug Administration convened a global multidisciplinary workshop to address the unmet clinical need to promote and accelerate the development of pediatric-specific heart valve technologies.
Methods: The Pediatric Heart Valve Global Multidisciplinary Workshop was convened in October 2022. Key stakeholders, including expert clinicians in pediatric cardiology and cardiac surgery, valve manufacturers, engineers and scientists were assembled to review the current state-of-the-art, discuss unique challenges in the pre-and post-market evaluation of pediatric valve therapies, and highlight emerging technologies that show potential to address some of the key unmet needs of children with valve disease.
Behavior of leadless atrioventricular synchronous pacing during exercise.
Heart Rhythm
November 2024
Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium; Cardiology, University Hospitals Leuven, Leuven, Belgium.
Background: The leadless Micra AV pacemaker is designed to provide atrioventricular (AV) synchronous tracking by detecting atrial contraction. Detection of the mechanical atrial signals can become challenging at a fast sinus rate.
Objective: The purpose of the study was to evaluate the AV synchronous performance during exercise in outpatients implanted with a Micra AV pacemaker.
Blepharoplasty: Difficult Cases.
Clin Plast Surg
January 2025
Department of Plastic Surgery, Post-Graduate Aesthetic Fellowship, Section of Aesthetic Surgery, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A-60, Cleveland, OH, USA. Electronic address:
Lower lid blepharoplasty surgery can be a challenging procedure for both the neophyte and the accomplished surgeon. It requires mastering complex periorbital anatomy and choosing the correct approach from a wide variety of patient presentations. This article spans the meticulous clinical evaluation, diagnostic approaches, and surgical techniques required to address challenging clinical scenarios of the lower eyelid, lid-cheek junction, and midface.
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