AI Article Synopsis
- The study aimed to assess how phototherapeutic keratectomy (PTK) affects healing in rabbit corneas with persistent superficial ulcers caused by burn injuries.
- PTK was compared with a control method involving scraping; results showed that PTK improved epithelial healing and reduced corneal opacity.
- Electron microscopy revealed that PTK stimulated healing activities in both epithelial and stromal cells, leading to better tissue recovery and restoration of corneal structure.
Article Abstract
Purpose: To evaluate epithelial and stromal healing of kakali-bumed rabbit corneas with persistent superficial ulceration after phototherapeutic keratectomy (PTK).
Material And Methods: 36 rabbits (36 eyes), with superficial corneal ulcers, which were formed after 10% NaOH corneal burn, were used. PTK was performed on the 18th day after the burn in 18 rabbits. The base and edges of corneal ulcers in 18 other rabbits were scraped with scalpel on the 18th day after the burn (control group). Clinical course and electron microscopic changes of post-burn corneal ulcers were investigated after PTK and in the control group.
Results: Clinical course of corneal ulcers has shown that PTK promoted corneal epithelialization and led to formation of less dense corneal opacities compared to control group. Electron microscopy investigations have shown that PTK (1) activated basal layer epithelial cells at the corneal ulcer edge; (2) accelerated epithelial basal complex renewal; (3) increased amount of macrophages with cytoplasmic inclusions of necrotic tissues in corneal stroma; (4) increased amount of fibroblasts with activated intracellular organellae in corneal stroma. It led to acceleration of corneal epithelization, cleaning of corneal stroma from necrotic tissues in the area of corneal ulcer and to more physiologic stromal architecture renewal.
Conclusions: PTK promotes healing of post-burn persistent corneal ulcers in rabbits.
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