An examination was performed on 16 intraductal proliferative breast lesions diagnosed as intraductal papillomas (IP) or usual ductal hyperplasia (UDH), which were followed up for more than 3 years. An immunohistochemical marker panel combining myoepithelial markers, high-molecular-weight keratin (HMWK) and neuroendocrine markers was used. Two of 11 IP cases were re-evaluated as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS). These cases developed breast cancer after the first operation. One IP case showed repeated recurrences. None of the other IP and UDH cases had breast cancer or recurrence. The ADH, DCIS and the recurrent IP showing a solid growth lacked myoepithelia, but the recurrent IP expressed HMWK, immunohistochemically. Interestingly, these three lesions were weakly positive for neuroendocrine markers. All other IPs and UDHs, including lesions having solid components, were negative for neuroendocrine markers, and most of them were positive for myoepithelial markers and/or HMWK. A combination of the above immunohistochemical markers seems useful to evaluate intraductal proliferative lesions and to predict their prognosis. In particular, intraductal proliferative lesions with solid components exhibiting positivity for neuroendocrine markers should be followed up carefully to monitor breast cancer risk or recurrence.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.14670/HH-26.79 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ductal Carcinoma In Situ of the Breast in Sclerosing Adenosis Mimicking Microinvasive Ductal Carcinoma: A Rare Case Report.
Clin Case Rep
December 2024
Division of General Surgery, Department of Surgery Tri-Service General Hospital, National Defense Medical Center Taipei Taiwan.
Sclerosing adenosis (SA) is a subtype of adenosis characterized by proliferative adenosis and stromal sclerosis with distortion of the terminal ductal lobular unit. Although SA is the most prevalent benign breast condition among middle-aged women, it may be associated with a two-fold increase in breast cancer risk. Microscopic findings of ductal carcinoma in situ (DCIS) in a SA (SA-DCIS) may mimic microinvasive carcinoma or even invasive carcinoma, which may result in overtreatment by a breast surgeon.
View Article and Find Full Text PDFDuctal hamartoma of the pancreas: A clinicopathologic study.
Hum Pathol
November 2024
Yale University School of Medicine, Department of Pathology, New Haven, CT, USA. Electronic address:
Article Synopsis
- Benign ductular proliferative lesions resembling hepatic von-Meyenburg Complexes have been identified in the pancreas, termed pancreatic ductal hamartomas (PDH), but their characteristics and causes are still unclear.
- A study reviewed three cases of PDH found during evaluations for other pancreatic conditions, often misdiagnosed as intra-ductal pancreatic mucinous cystic neoplasms, leading to surgical removal.
- PDH were found incidentally in 4.5% of pancreatic resections, showing varied sizes and histological features, but their connection to pancreatic cancer or IPMN remains uncertain.
Trajectory of Subsequent Breast Cancer Diagnoses in a Diverse Patient Cohort with Breast Atypia.
Ann Surg Oncol
October 2024
Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Article Synopsis
- Proliferative breast atypical lesions, like atypical ductal hyperplasia (ADH) and lobular intraepithelial neoplasms (LIN), increase the risk for developing ductal carcinoma in situ (DCIS) and invasive breast cancer (IBC), though the timing for progression varies widely.
- A study of 418 patients diagnosed with these lesions revealed that 17% developed either IBC or DCIS, with almost half of these cases occurring within 5 years after the initial diagnosis.
- Neither patient demographics nor clinical features were linked to the timing or likelihood of developing subsequent cancer events, indicating that atypia is a significant marker for overall malignancy risk.
Multiplicity of benign breast disease lesions and breast cancer risk in African American women.
Front Oncol
May 2024
Department of Oncology, Wayne State University School of Medicine, Detroit, MI, United States.
The risk of developing subsequent breast cancer is higher in women diagnosed with benign breast disease (BBD) but these studies were primarily performed in non-Hispanic white populations. Still, these estimates have been used to inform breast cancer risk models that are being used clinically across all racial and ethnic groups. Given the high breast cancer mortality rates among African American (AA) women, it is critical to study BBD in this population, to ensure the risk models that include this information perform adequately.
View Article and Find Full Text PDFMeibomian Gland Probing Stimulates a Proliferative Epithelial Response Resulting in Duct Regeneration.
Clin Ophthalmol
March 2024
Dry Eye and Cornea Treatment Center, Tampa, FL, USA.
Purpose: To demonstrate that the meibomian gland ductal basement membrane and basal epithelial cell layer are in continuity with and may derive from lid margin orifice-associated rete ridge epithelial/basement membrane structures (OARREBS) and to characterize changes in the distal duct microanatomy after meibomian gland probing (MGP) using in vivo confocal microscopy (IVCM).
Patients And Methods: Pre/post-MGP IVCM examinations were performed on upper lids. Thirty-six identical glands from 20 lids of 16 patients (49.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!