Objective. Rare case presentation of thyroid cartilage variation causing globus sensation and dysphagia. Method. Case report and review of the literature concerning thyroid cartilage variant of clinical significance. Results. Middle-aged male patient presented with globus sensation and painful swallow without previous injury of the larynx. Clinical examination and diagnostic procedures revealed a rare anatomic aberrance of the thyroid cartilage. Surgical treatment was declined by the patient who accepted a yearly followup. Conclusion. Morphometric studies do not report the dislocation of the superior thyroid cornu, and very few cases have been described either of which were attributed to trauma or to unknown cause. The present case is to be added to the very few cases of superior thyroid cornu dislocation of unknown aetiology. Clinicians should be aware of this rare variation using CT neck as the imaging study of choice. Direct endoscopy rules out any synchronous disease or malignancies.
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http://dx.doi.org/10.1155/2010/142928 | DOI Listing |
J Med Chem
December 2024
Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Rearranged during transfection (RET) kinase is a validated therapeutic target for various cancers characterized by RET alterations. Although two selective RET inhibitors, selpercatinib and pralsetinib, have been approved by the FDA, acquired resistance through solvent-front mutations has been identified rapidly. Developing proteolysis targeting chimera (PROTAC) targeting RET mutations offers a promising strategy to combat drug resistance.
View Article and Find Full Text PDFAdv Physiol Educ
December 2024
Departamento de Fisiologia e Biofisica, Universidade de Sao Paulo, Sao Paulo, Brazil.
Games and analogies can significantly enrich the learning experience when integrated with traditional expository teaching methods. With this aim, we developed The Mystery of the Cell Kingdom, an online game designed to enhance understanding of the physiology of thyroid hormones through a medieval analogy. In the game, students are challenged to apply their knowledge of endocrine physiology to solve a series of relevant questions on the topic.
View Article and Find Full Text PDFAnn Ital Chir
December 2024
Radiotherapy Department, Affiliated Hospital of Hebei University, 071003 Baoding, Hebei, China.
Head Neck
December 2024
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.
Background: This study aimed to evaluate the safety, efficacy, and oncologic outcomes of thermal ablation techniques, including radiofrequency, laser, and microwave ablation, in treating primary thyroid cancer compared with surgical resection.
Method: We conducted a systematic review and network meta-analysis, which included 21 comparative studies and 40 noncomparative studies.
Results: The three thermal ablation techniques showed significant superiority over surgical resection in terms of operative time, pain, cost, quality of life, and complications.
J Bone Oncol
February 2025
Center of Radiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Unlabelled: Bone metastasis from breast cancer significantly elevates patient morbidity and mortality, making early detection crucial for improving outcomes. This study utilizes radiomics to analyze changes in the thoracic vertebral bone marrow microenvironment from chest computerized tomography (CT) images prior to bone metastasis in breast cancer, and constructs a model to predict metastasis.
Methods: This study retrospectively gathered data from breast cancer patients who were diagnosed and continuously monitored for five years from January 2013 to September 2023.
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