AI Article Synopsis
- Photodynamic therapy (PDT) utilizes a photosensitizer drug activated by laser light to target and ablate diseased tissue, particularly effective in treating Barrett's esophagus, high-grade dysplasia, and early esophageal adenocarcinoma.
- While Porfimer sodium has shown promise, its use is restricted due to significant side effects like prolonged skin sensitivity and the formation of strictures.
- Ongoing research focuses on improving PDT by enhancing dosimetry, understanding tissue properties, and considering individual genetic factors for better safety and efficacy.
Article Abstract
Photodynamic therapy (PDT) is a photochemical process that uses a photosensitizer drug activated by laser light to produce mucosal ablation. Porfimer sodium PDT has proved long-term efficacy and durability in the treatment of Barrett's esophagus and high-grade dysplasia and early esophageal adenocarcinoma. Its use has been limited by serious side effects including prolonged cutaneous photosensitivity and stricture formation. Other photosensitizers with a better safety profile have been used mostly in Europe with limited experience. The future of PDT lies on a better understanding of dosimetry, tissue properties, and host genetic factors.
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| http://dx.doi.org/10.1016/j.giec.2010.09.002 | DOI Listing |
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