AI Article Synopsis
- Researchers created a technique using quantum dots (QDs) to visualize surface charges on biological cells at a nano-scale level.* -
- The QDs, made from amino-modified CdSe/ZnS nanoparticles, are positively charged and can label negative charges on living cell surfaces when dispersed in a special buffer solution.* -
- This method allows for 2D/3D imaging of cells, providing important data on charge densities, which is crucial for understanding cell structure, function, behavior, and potential malignancy.*
Article Abstract
We developed a technique using quantum dot (QD) as a sensor for quantitative visualization of the surface charge on biological cells with nano-scale resolution. The QD system was designed and synthesized using amino modified CdSe/ZnS nanoparticles. In a specially designed buffer solution, they are positively charged and can homogeneously disperse in the aqueous environment to label all the negative charges on the surfaces of living cells. Using a wide-field optical sectioning microscopy to achieve 2D/3D imaging of the QD-labeled cells, we determined the charge densities of different kinds of cells from normal to mutant ones. The information about the surface charge distribution is significant in evaluating the structure, function, biological behavior and even malignant transformation of cells.
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| http://dx.doi.org/10.1016/j.bios.2010.09.016 | DOI Listing |
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