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Mitochondria-Nucleus Migration Probe for Ultrasensitive Monitoring of mtDNA Damage in Living Cells.
Anal Chem
December 2024
School of Chemistry and Chemical Engineering University of Jinan, Jinan 250022, People's Republic of China.
Mitochondrial DNA (mtDNA) damage is a prevalent phenomenon that has been proven to be implicated in a wide spectrum of diseases. However, the progressive attenuation of probe signals in response to mtDNA damage within living cells inherently limits the sensitivity and precision of current probes for detecting mtDNA damage. Herein, we employ an innovative organelle signal ratio imaging approach, utilizing the mitochondria-nucleus migration probe MCQ, to achieve unparalleled sensitivity in detecting mtDNA damage in living cells.
View Article and Find Full Text PDFApplication of green silver nano-particles as anti-bacterial and photo-catalytic degradation of azo dye in wastewater.
Sci Rep
December 2024
Sustainability Solutions Research Lab, Faculty of Engineering, University of Pannonia, Egyetem Str. 10, Veszprém, 8200, Hungary.
Ensuring everyone enjoys healthy lifestyles and well-being at all ages, Progress has been made in increasing access to clean water and sanitation facilities and reducing the spread of epidemics and diseases. The synthesis of nano-particles (NPs) by using microalgae is a new nanobiotechnology due to the use of the biomolecular (corona) of microalgae as a capping and reducing agent for NP creation. This investigation explores the capacity of a distinct indigenous microalgal strain to synthesize silver nano-particles (AgNPs), as well as its effectiveness against multi-drug resistant (MDR) bacteria and its ability to degrade Azo dye (Methyl Red) in wastewater.
View Article and Find Full Text PDFHomogenous catalysis of peroxynitrite conversion to nitrate by diaryl selenide: a theoretical investigation of the reaction mechanism.
Front Chem
December 2024
Department of Chemistry, Cleveland State University, Cleveland, OH, United States.
Quenching peroxynitrite (a reactive oxidant species) is a vital process in biological systems and environmental chemistry as it maintains redox balance and mitigates damaging effects in living cells and the environment. In this study, we report a systematic analysis of the mechanism of transforming peroxynitrite into nitrate using diaryl selenide in water. Through quantum mechanical calculations, we investigate the dynamic isomerization of peroxynitrite in a homogeneous catalytic environment.
View Article and Find Full Text PDFCytoprotective Effects and Intranuclear Localization of Sulfur-Containing Derivative of Buckminsterfullerene.
Front Biosci (Landmark Ed)
December 2024
Research Centre for Medical Genetics, 115522 Moscow, Russia.
Background: There is a growing interest in exploring the biological characteristics of nanoparticles and exploring their potential applications. However, there is still a lack of research into the potential genotoxicity of fullerene derivatives and their impact on gene expression in human cells. In this study, we investigated the effects of a water-soluble fullerene derivative, C60[C6H4SCH2COOK]5H (F1), on human embryonic lung fibroblasts (HELF).
View Article and Find Full Text PDFRecent Progress in Atomically Precise Cu-M Alloy Nanoclusters.
Chemistry
December 2024
Huazhong University of Science and Technology, School of Materials Science and Engineering, CHINA.
Metal nanoclusters (NCs) with dimensions of approximately 3 nm serve as a crucial link between metal-organic complexes and metal nanoparticles, garnering significant interest due to their distinctive molecule-like characteristics. These include well-defined molecular structures, clear HOMO-LUMO transitions, quantized charge, and robust luminescence emission. Atomically precise alloy NCs, in contrast to homometallic NCs, exhibit a wealth of structures and intriguing properties, with their novel attributes often intricately tied to the positions of alloyed elements within the structure, facilitating the exploration of structure-property relationships.
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