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http://dx.doi.org/10.1002/anie.201005212 | DOI Listing |
Acc Chem Res
January 2025
Department of Chemistry, Northeast Normal University, Changchun 130024, China.
ConspectusIn the past decade, single-atom skeletal editing, which involves the precise insertion, deletion, or exchange of single atoms in the core skeleton of a molecule, has emerged as a promising synthetic strategy for the rapid construction or diversification of complex molecules without laborious synthetic processes. Among them, carbene-initiated skeletal editing is particularly appealing due to the ready availability and diverse reactivities of carbene species. The initial endeavors to modify the core skeleton of heteroarenes through carbon-atom insertion could date back to 1881, when Ciamician and Denstedt described the conversion of pyrroles to pyridines by trapping haloform-derived free carbene.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2011
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
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