AI Article Synopsis
- rt-PA is the only approved drug for treating acute ischemic stroke but can lead to serious side effects like intracranial hemorrhage and allergic reactions.
- Patients on ACE inhibitors may have a higher risk of experiencing these allergic reactions.
- The report highlights a case of a patient who had a severe anaphylactoid shock after receiving rt-PA, prompting a discussion on the link between rt-PA and ACE inhibitors.
Article Abstract
Recombinant tissue plasminogen activator (rt-PA) is currently the only approved agent for treating acute ischemic stroke. However, rt-PA may cause fatal symptomatic intracranial hemorrhage and other adverse effects like bleeding complications and allergic reactions. Patients taking angiotensin-converting enzyme (ACE) inhibitors have increased risk of allergic reactions. This report is about a patient with a history of ACE inhibitor intake who experienced life-threatening anaphylactoid shock during rt-PA administration. The relationship between rt-PA and ACE inhibitor was also discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ajem.2010.10.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Differences in hypersensitivity reactions and gadolinium deposition disease/symptoms associated with gadolinium exposure to gadolinium-based contrast agents: new insights based on global databases VigiBase, FAERS, and IQVIA-MIDAS.
BMC Med
August 2024
Department of Pharmacy, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, No.1279 Sanmen Road, Shanghai, 200434, People's Republic of China.
Background: Hypersensitivity reactions (HSRs) can occur unexpectedly and be life-threatening when gadolinium-based contrast agents (GBCAs) are used. Gadolinium deposition disease (GDD) and symptoms associated with gadolinium exposure (SAGE) have been controversial for a long time. However, similar studies are currently incomplete or outdated.
View Article and Find Full Text PDFHeparin-induced thrombocytopenia (HIT) is a rare and life-threatening autoimmune-mediated adverse drug reaction seen in patients who are exposed to various forms of pharmacological heparin, including unfractionated heparin (UFH) and low molecular weight heparin (LMWH). Despite the presence of thrombocytopenia, these patients face the risk of clot formation and bleeding simultaneously. Prompt cessation of heparin and the initiation of non-heparin anticoagulants are important for the patient's survival.
View Article and Find Full Text PDFThe bradykinin-forming cascade in anaphylaxis and ACE-inhibitor induced angioedema/airway obstruction.
Front Allergy
January 2024
Division of Pulmonary and Critical Care Medicine, The Medical University of South Carolina, Charleston, SC, United States.
Article Synopsis
- Anaphylaxis is a serious allergic reaction that affects multiple body systems, usually the skin, lungs, heart, and gastrointestinal tract, and can cause severe symptoms like shock or airway obstruction.
- There are two types of triggers: immunologic, which involves the binding of foreign antigens to IgE on mast cells and basophils, and non-immunologic, which can occur through various mechanisms including direct activation of mast cells or immune complex activation.
- The report highlights the role of the bradykinin-forming cascade in severe anaphylaxis symptoms and discusses how disruptions in bradykinin metabolism can contribute to airway obstruction and significant complications.
Does First-Use Syndrome Happen During Apheresis? A Case Report.
Cureus
May 2023
Medicine, Dhaka Medical College Hospital, Dhaka, BGD.
Steam, dry heat, radiation, ethylene oxide gas, evaporated hydrogen peroxide, and many other sterilization methods are used to sanitize medical equipment (e.g., chlorine dioxide gas, nitrogen dioxide, and vaporized peracetic acid).
View Article and Find Full Text PDFAnaphylaxis Following Contrast-Enhanced CT with Iodixanol: A Case Report and Literature Review.
J Asthma Allergy
January 2023
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Background: Iodixanol-induced anaphylactic reaction is a well-known adverse event of contrast agents, which are generally well-tolerated and reversible. Serious and fatal reactions such as anaphylactic shock after computed tomography (CT) enhancement have been described. However, there is no data on these events in the literature.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!