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Role of RGS17 in cisplatin-induced cochlear inflammation and ototoxicity via caspase-3 activation.
Front Immunol
March 2025
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, United States.
Cisplatin is a chemotherapy drug used to treat different solid tumors, including ovarian, bladder, lung, and head and neck cancers. One of its significant side effects is ototoxicity, especially when high doses are required. Cisplatin-induced ototoxicity is associated with increased cochlear cell death resulting from DNA damage, caspase activation, oxidative stress, inflammation, and glutamate excitotoxicity.
View Article and Find Full Text PDFArtesunate attenuates skin hypertrophic scar formation by inhibiting fibroblast activation and EndMT of vascular endothelial cells.
Phytomedicine
February 2025
State Key Laboratory of Trauma and Chemical Poisoning, Institute of Burn Research, First Affiliated Hospital of Army Medical University (Third Military Medical University), Chongqing 400038, China; Chongqing Key Laboratory for Wound Repair and Tissue Regeneration, Chongqing 400038, China. Electronic address:
Background Hypertrophic scarring is an abnormal condition involving excessive fibroblast activation, aberrant extracellular matrix deposition, and persistent inflammation. Current treatments have limited efficacy and potential adverse effects, necessitating the development of new approaches. Purpose In this study, we investigated the effects of artesunate (ART) on hypertrophic scar (HS) formation and explored the underlying cellular and molecular mechanisms.
View Article and Find Full Text PDFCornea specialists are the highest opioid prescribers at a large academic eye institute in the USA.
BMJ Open Ophthalmol
March 2025
Massachusetts Eye and Ear Department of Ophthalmology, Boston, Massachusetts, USA
Background/aim: To evaluate the opioid prescription patterns across ophthalmic subspecialties at a large academic eye centre.
Methods: A single site, retrospective cross-sectional study. Electronic medical records from the year 2018 were screened.
Constitutive and hypoxia-induced VEGF production by cultured uveal melanocytes and retinal pigment epithelial cells.
Exp Eye Res
March 2025
New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA; Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:
Constitutive secretion of VEGF is crucial for maintaining ocular circulation while hypoxia-induced VEGF secretion plays an important role in pathological neovascularization. Previous studies have highlighted the critical function of RPE cells in these situations. The role of uveal melanocytes (UM) in VEGF production, however, has not been well described.
View Article and Find Full Text PDFThe human ear has emerged as a bidirectional gateway to the brain's and body's signals. Recent advances in around-the-ear and in-ear sensors have enabled the assessment of biomarkers and physiomarkers derived from brain and cardiac activity using ear-electroencephalography (ear-EEG), photoplethysmography (ear-PPG), and chemical sensing of analytes from the ear, with ear-EEG having been taken beyond-the-lab to outer space. Parallel advances in non-invasive and minimally invasive brain stimulation techniques have leveraged the ear's access to two cranial nerves to modulate brain and body activity.
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