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Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway.
Biochem Pharmacol
March 2025
Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, China; Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China. Electronic address:
Steroid-induced avascular necrosis of the femoral head (SANFH) is a progressive degenerative disease of the hip, primarily due to glucocorticoid (GC)-induced endothelial cell (EC) injury and compromised blood supply. Irisin is an EC-protective mytokine whose receptor is the integrin αVβ5. Caveolin-1 (CAV-1)， a major component of caveolae, causes endothelial dysfunction when phosphorylated.
View Article and Find Full Text PDFMicrocytosis Merits Evaluation: A Case Report of Hemoglobin S With Hereditary Persistence of Fetal Hemoglobin (HbS-HPFH Syndrome).
Cureus
February 2025
Hematology-Oncology, Veterans Affairs Greater Los Angeles Health System, Los Angeles, USA.
Microcytosis is commonly encountered in primary care. Among patients with normal iron stores or compatible family history, hemoglobin electrophoresis, traditionally performed with gel electrophoresis and now through combination capillary electrophoresis/high-performance liquid chromatography, can diagnose thalassemic disorders or, rarely, a hemoglobinopathy. We present a case of an incidentally discovered microcytosis in a 34-year-old male patient where the workup led to a diagnosis of Hemoglobin S with Hereditary Persistence of Fetal Hemoglobin (HbS-HPFH syndrome).
View Article and Find Full Text PDFIn-hospital versus postdischarge 30-day mortality in patients admitted after acute myocardial infarction (AMI), cerebral stroke or hip fracture: a cohort study based on registry data.
BMJ Open Qual
March 2025
South-Eastern Norway Regional Health Authority, Hamar, Norway.
Background: 30-day mortality is frequently used to monitor and improve patient safety and quality of care. In this study, we compare 30-day mortality according to place of death, that is, during admission (in-hospital), postdischarge or after readmission for patients with acute myocardial infarction (AMI), cerebral stroke and hip fracture.
Methods: Administrative data for patients admitted with AMI, cerebral stroke and hip fractures to Norwegian hospitals between 2017 and 2019 were obtained from the Norwegian Patient Registry, enabling the estimation of mortality and readmission proportions.
Legg-Calvé-Perthes disease- surgical treatment options.
Arch Orthop Trauma Surg
March 2025
Medical Park Klinik, Bad Wiessee, Germany.
Legg-Calvé-Perthes disease (LCPD), is a rare avascular osteonecrosis of the proximal femur usually occurring in children between 5 and 10 years of age. The cause of ischemia leading to necrosis of the femoral head remains unknown. The goal of surgical treatment for LCPD is to improve the containment of the femoral head to restore the function of the hip joint and prevent further damage to the femoral head leading to premature hip osteoarthritis.
View Article and Find Full Text PDFMedial opening wedge valgus intertrochanteric osteotomy for femoral neck nonunion: a femoral anatomy-preserving surgical approach.
Hip Int
March 2025
Department of Orthopaedics unit 3, Christian Medical College, Vellore, India.
Background: Valgus osteotomy is a femoral head-preserving surgery to treat femoral neck non-union in young, active patients. The traditional approach, however, causes medialisation of the femoral shaft during valgus correction, which alters femoral anatomy and complicates conversion to total hip arthroplasty if head osteosynthesis fails. This study aims to outline a novel surgical technique, medial opening wedge valgus intertrochanteric osteotomy (VITO), and evaluate its clinical and radiographic outcomes, focusing on restoring hip biomechanics and improving union rates.
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