[Changes of oxidative and antioxidative properties of blood under the action of perftoran in patients with acute sensorineural loss of hearing].

The authors report the results of examination and treatment of 100 patients presenting with acute sensorineural loss of hearing using audiological and biochemical methods. General oxidative (GO) and antioxidative (GAO) activities, malonic dialdehyde (MDA) and catalase (C) levels in blood plasma were measured in 60 patients given original perftoran-based therapy and in 40 patients receiving traditional treatment. Management of acute sensorineural loss of hearing with the use of perftoran proved efficacious in 95% of the cases compared with 80% using traditional therapy. Plasma oxidative activity decreased and antioxidative activity increased within 1 week after infusion of perftoran. These changes correlated with positive functional outcomes of the treatment.