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Construction of Immune Single Domain Antibodies Library for Development of Specific Nanobodies Using Phage Display Strategy.
Recent Pat Biotechnol
January 2025
Center of Excellence in Recombinant Biopharmaceutical Proteins, Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Background: poses a considerable global public health challenge. In Egypt, approximately 60% of the inhabitants in the Northern and Eastern areas of the Nile Delta are affected by this parasite, whereas the Southern region experiences a significantly lower infection rate of 6%.
Aim: Construction of an immune phage display Nbs library based on the VHH framework for selecting -specific Nbs for seeking cost-effective, sensitive, and specific diagnostic tools for rapidly detecting mansoni.
Dissemination of clinical harboring the gene in Pakistan.
Front Microbiol
January 2025
Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan.
Background: Colistin is an antibiotic used as a last resort to treat multidrug-resistant Gram-negative bacterial infections. Plasmid-mediated mobile colistin-resistant () genes in () are disseminated globally and are considered to be a major public health threat. This study aimed to determine the molecular characteristics of colistin-resistant isolates in clinical settings in Pakistan.
View Article and Find Full Text PDFAssociation of GLP1R locus with mental ill-health endophenotypes and cardiometabolic traits: A trans-ancestry study in UK Biobank.
Diabetes Obes Metab
January 2025
School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Aims: Glucagon-like peptide 1 receptor agonists (GLP1RA), used to treat type 2 diabetes and obesity, have been associated with off-target behavioural effects. We systematically assessed genetic variation in the GLP1R locus for impact on mental ill-health (MIH) and cardiometabolic phenotypes across diverse populations within UK Biobank.
Materials And Methods: All genetic variants with minor allele frequency >1% in the GLP1R locus were investigated for associations with MIH phenotypes and cardiometabolic phenotypes.
Anticancer Properties of Phenylboronic Acid in Androgen-Dependent (LNCaP) and Androgen-Independent (PC3) Prostate Cancer Cells via MAP Kinases by 2D and 3D Culture Methods.
Anticancer Agents Med Chem
January 2025
Department of Histology and Embryology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Türkiye.
Objective: This study utilized three cell lines: normal prostate epithelial RWPE-1, androgen-dependent LNCaP, and androgen-independent PC3. We investigated the inhibitory effects of phenylboronic acid (PBA)'s inhibitory effect on cellular proliferation due to its ability to disrupt microtubule formation in prostate cancer cell lines. Additionally, this study aimed to assess the cytotoxic effects of PBA on prostate cancer cells using twodimensional (2D) and three-dimensional (3D) cell culture models.
View Article and Find Full Text PDFGenome-wide identification of MGT gene family in soybean (Glycine max) and their expression analyses under magnesium stress conditions.
BMC Plant Biol
January 2025
Faculty of Biotechnology, October University for Modern Sciences & Arts, 6th October City, Egypt.
Background: Magnesium (Mg) is essential for plant growth and development and plays critical roles in physiological and biochemical processes. Mg deficiency adversely affects growth of plants by limiting shoot and root development, disturbing the structure and membranes of the grana, reducing photosynthesis efficiency, and lowering net CO assimilation. The MGT (Magnesium transporter) family is responsible for the absorption and transportation of magnesium in plants.
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