AI Article Synopsis
- - The study investigates how variations (polymorphisms) in the SMAD4 gene are linked to the risk of gastric cancer, focusing on a Chinese population by comparing cancer patients with healthy controls.
- - Researchers analyzed five tagging single nucleotide polymorphisms (tSNPs) in the SMAD4 gene, discovering that specific genetic variants significantly reduce the risk of developing gastric cancer.
- - The findings indicate that individuals with fewer protective alleles from these genetic variants also show lower levels of SMAD4 protein expression in normal tissues near tumors, suggesting a potential protective role of SMAD4 variants against gastric cancer.
Article Abstract
Aim: To explore the association between mothers against decapentaplegic homolog 4 (SMAD4) gene polymorphisms and gastric cancer risk.
Methods: Five tagging single nucleotide polymorphisms (tSNPs) in the SMAD4 gene were selected and genotyped in 322 gastric cancer cases and 351 cancer-free controls in a Chinese population by using the polymerase chain reaction restriction fragment length polymorphism method. Immunohistochemistry was used to examine SMAD4 protein expression in 10 normal gastric tissues adjacent to tumors.
Results: In the single-locus analysis, two significantly decreased risk polymorphisms for gastric cancer were observed: the SNP3 rs17663887 TC genotype (adjusted odds ratio = 0.38, 95% confidence interval: 0.21-0.71), compared with the wild-type TT genotype and the SNP5 rs12456284 GG genotype (0.31, 0.16-0.60), and with the wild-type AA genotype. In the combined analyses of these two tSNPs, the combined genotypes with 2-3 protective alleles (SNP3 C and SNP5 G allele) had a significantly decreased risk of gastric cancer (0.28, 0.16-0.49) than those with 0-1 protective allele. Furthermore, individuals with 0-1 protective allele had significantly decreased SMAD4 protein expression levels in the normal tissues adjacent to tumors than those with 2-3 protective alleles (P = 0.025).
Conclusion: These results suggest that genetic variants in the SMAD4 gene play a protective role in gastric cancer in a Chinese population.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992684 | PMC |
| http://dx.doi.org/10.3748/wjg.v16.i44.5635 | DOI Listing |
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