AI Article Synopsis
- The research explores the creation of multifunctional nanostructures using G-quadruplex motifs, which have potential as therapeutic carriers.
- The study focuses on synthesizing a polymer conjugate with G15-mer oligonucleotides, demonstrating their ability to self-assemble into organized structures.
- The assembled structures can effectively bind therapeutic agents, revealing promise for drug delivery applications through multilayer films and microcapsules.
Article Abstract
The assembly of multifunctional nanostructures bearing G-quadruplex motifs broadens the prospects of using G-quadruplexes as therapeutic carriers. Herein, we report the synthesis and characterization of an oligodeoxyguanosine, G15-mer polymer conjugate. We demonstrate that G15-mer oligonucleotides grafted to a polymer chain preserve the ability to self-assemble into ordered structures. The G-quadruplex-polymer conjugates were assembled onto a surface via hybridization with 30-mer cytosine strands, C30-mer, using a layer-by-layer approach to form microcapsules. A mechanism for the sequential assembly of the multilayer films and microcapsules is presented. We further investigate the photophysical behavior of porphyrin TMPyP4 bound to multilayer-coated particles. This study shows that the multilayer films bear residual and functional quadruplex moieties that can be used to effectively bind therapeutic agents.
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| http://dx.doi.org/10.1002/smll.201001246 | DOI Listing |
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