AI Article Synopsis
- A 34-year-old woman experienced abdominal pain, jaundice, and itching, leading to an ERCP procedure that initially appeared normal.
- Using a balloon catheter for cholangiography revealed irregularities suggestive of early-stage primary sclerosing cholangitis (PSC), a chronic liver condition affecting bile ducts.
- The standard ERCP typically shows characteristic findings for PSC, but early diagnosis can be tricky; the balloon catheter technique may enhance detection of early changes in the bile ducts.
Article Abstract
A 34-year-old woman was admitted to our clinic with abdominal pain, jaundice and pruritus. Endoscopic retrograde cholangiopancreatography was performed for cholestasis. Endoscopic retrograde cholangiopancreatography (ERCP) was judged as normal, after a standard ERCP cannula was used for the cholangiogram. However, marked canalicular irregularities were identified in cholangiography when pressurized contrast agent was administrated via balloon catheter. This cholangiographic view was thought to reveal an early-stage alteration of sclerosing cholangitis. Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by destruction and fibrosis of the bile ducts. The diagnosis of PSC is based on typical cholangiographic findings, supported by nonspecific clinical signs and symptoms, cholestatic liver biochemical tests, and liver biopsy. Cholangiography is considered to be the gold standard for the diagnosis of PSC. The diagnosis is easy when diffuse multifocal biliary strictures, the hallmarks of the disease, resulting in a 'beaded' appearance on ERCP is detected. However, it may reveal a normal image in an early stage of the disease when bile duct changings are not prominent. We think that balloon catheter ERCP appears to facilitate the diagnosis of early-stage primary sclerosing cholangitis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988889 | PMC |
| http://dx.doi.org/10.1159/000272408 | DOI Listing |
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Article Synopsis
- Primary sclerosing cholangitis is a chronic liver condition associated with inflammation and fibrosis of bile ducts, often linked to inflammatory bowel disease and increases the risk of cancer.
- Current treatments mainly offer supportive care, as there are no effective medical therapies available and liver transplantation can prolong life but does not cure the disease.
- Research is ongoing into new therapies aimed at slowing disease progression and alleviating symptoms, with improved trial designs focused on selecting appropriate patients and using better outcome measures to assess treatment effectiveness.
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