We describe a programmable spatial-filtering system using bacteriorhodopsin (BR) film as a programmable, optically addressed spatial light modulator illuminated by a single wavelength of light. We use a computer-controlled mirror scanning system to write time-varying filter functions to the BR film and present proof-of-principle experimental results that demonstrate several elementary filtering operations.
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http://dx.doi.org/10.1364/AO.35.004632 | DOI Listing |
Acc Chem Res
January 2025
Department of Chemistry, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel.
ConspectusA key challenge in modern chemistry research is to mimic life-like functions using simple molecular networks and the integration of such networks into the first functional artificial cell. Central to this endeavor is the development of signaling elements that can regulate the cell function in time and space by producing entities of code with specific information to induce downstream activity. Such artificial signaling motifs can emerge in nonequilibrium systems, exhibiting complex dynamic behavior like bistability, multistability, oscillations, and chaos.
View Article and Find Full Text PDFBrief Bioinform
November 2024
Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
Spatially resolved transcriptomics (SRT) technologies facilitate the exploration of cell fates or states within tissue microenvironments. Despite these advances, the field has not adequately addressed the regulatory heterogeneity influenced by microenvironmental factors. Here, we propose a novel Spatially Aligned Graph Transfer Learning (SpaGTL), pretrained on a large-scale multi-modal SRT data of about 100 million cells/spots to enable inference of context-specific spatial gene regulatory networks across multiple scales in data-limited settings.
View Article and Find Full Text PDFJ Comput Neurosci
January 2025
Program in Neuroscience, Indiana University Bloomington, Bloomington, IN, USA.
Hippocampal representations of space and time seem to share a common coding scheme characterized by neurons with bell-shaped tuning curves called place and time cells. The properties of the tuning curves are consistent with Weber's law, such that, in the absence of visual inputs, width scales with the peak time for time cells and with distance for place cells. Building on earlier computational work, we examined how neurons with such properties can emerge through self-supervised learning.
View Article and Find Full Text PDFJ Racial Ethn Health Disparities
January 2025
Center for Economic and Social Research, Arts and Sciences, Dornsife College of Letters, University of Southern California, Los Angeles, USA.
Home visiting programs (HVPs) provide services to pregnant individuals and parents of young children to improve families' health and well-being. However, little is known about these families' social contexts. This study explores the social networks and dietary intake of mothers enrolled in a HVP, focusing on health support and health undermining.
View Article and Find Full Text PDFMed Biol Eng Comput
January 2025
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Temporal bone CT is an essential technique for diagnosing ossicular chain trauma, and the location of standard observation planes (SOP) is the foundation of imaging diagnosis. The ossicular chain is small in volume, and there are about 11 standard observation planes for ossicular chain diagnosis, so it is a professional and time-consuming task to label SOPs accurately. An automatic annotation method of SOP is proposed.
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