AI Article Synopsis

  • The study explores the use of terahertz pulsed imaging to differentiate between healthy and cirrhotic liver tissues, highlighting its effectiveness in identifying various organ tissues.
  • Measurements revealed that cirrhotic tissues contain more water and exhibit higher absorption coefficients compared to normal tissues, indicating distinct terahertz properties.
  • Even after fixing the samples in formalin, significant differences in terahertz characteristics persisted between healthy and diseased tissues, emphasizing the method's capability to detect changes due to both water content and structural alterations.

Article Abstract

We have previously demonstrated that terahertz pulsed imaging is able to distinguish between rat tissues from different healthy organs. In this paper we report our measurements of healthy and cirrhotic liver tissues using terahertz reflection spectroscopy. The water content of the fresh tissue samples was also measured in order to investigate the correlations between the terahertz properties, water content, structural changes and cirrhosis. Finally, the samples were fixed in formalin to determine whether water was the sole source of image contrast in this study. We found that the cirrhotic tissue had a higher water content and absorption coefficient than the normal tissue and that even after formalin fixing there were significant differences between the normal and cirrhotic tissues' terahertz properties. Our results show that terahertz pulsed imaging can distinguish between healthy and diseased tissue due to differences in absorption originating from both water content and tissue structure.

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http://dx.doi.org/10.1088/0031-9155/55/24/013DOI Listing

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