The estimation of human femur morphology and angulation provide useful information for assisted surgery, follow-up evaluation and prosthesis design, cerebral palsy management, congenital dislocation of the hip and fractures of the femur. Conventional methods that estimate femoral neck anteversion employ planar projections because accurate 3D estimations require complex reconstruction routines. In a recent work, we proposed a cylinder fitting method to estimate bifurcation angles in coronary arteries and we thought to test it in the estimation of femoral neck anteversion, valgus and shaft-neck angles. Femora from 10 patients were scanned using multisliced computed tomography. Virtual cylinders were fitted to 3 regions of the bone painted by the user to automatically estimate the femoral angles. Comparisons were made with a conventional manual method. Inter- and intra-reading measurements were evaluated for each method. We found femoral angles from both methods strongly correlated. Average anteversion, neck-shaft and valgus angles were 17.5°, 139.5°, 99.1°, respectively. The repeatability and reproducibility of the automated method showed a 5-fold reduction in inter- and intra-reading variability. Accordingly, the coefficients of variation for the manual method were below 25% whereas for the automated method were below 6%. The valgus angle assessment was globally the most accurate with differences below 1°. Maximum distances from true surface bone points and fitting cylinders attained 6 mm. The employment of virtual cylinders fitted to different regions of human femora consistently helped to assess true 3D angulations.
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http://dx.doi.org/10.1109/IEMBS.2010.5627701 | DOI Listing |
Alzheimers Dement
December 2024
GSK R&D, Stevenage, Hertfordshire, United Kingdom.
Background: Genetic variants in GRN, the gene encoding progranulin, are causal for or are associated with the risk of multiple neurodegenerative diseases. Modulating progranulin has been considered as a therapeutic strategy for neurodegenerative diseases including Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD). Here, we integrated genetics with proteomic data to determine the causal human evidence for the therapeutic benefit of modulating progranulin in AD.
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December 2024
University of Oxford, Oxford, Oxon, United Kingdom.
Background: An estimated ∼40% of dementia cases are due to modifiable risk factors which can be targeted in lifestyle interventions. Effective interventions employ face-to-face delivery, making them resource-intensive and burdensome. Digital interventions offer scalability, accessibility and cost-effectiveness.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Universidade Federal de São Paulo (UNIFESP), São Paulo, São Paulo/SP, Brazil.
Background: Dementia awareness and education are currently limited among healthcare workers and the general public, contributing towards the generation and propagation of stigma and discrimination against people with dementia worldwide. It is crucial to promote evidence-based anti-stigma interventions with a focus on stigma reduction.
Method: This is a randomized and controlled feasibility trial of a group intervention aimed at improving knowledge and reducing stigma related to dementia among Community Health Workers (CHWs) (Trial Registration: RBR-10xp637m).
Alzheimers Dement
December 2024
Postgraduate Program in Psychology, Salgado de Oliveira University, Rio de Janeiro, Rio de Janeiro, Brazil.
Background: The use of blood biomarkers predictive of the presence of amyloid Aβ and ApoE4 is an effective tool to facilitate a timely AD diagnosis. About a third of dementia cases can be attributed to potentially modifiable risk factors, and the incidence of the disease can be reduced by addressing these factors. Memory Workshops integrated with early detection and actions on risk factors is an operational strategy that is both therapeutic and preventive.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
WellBe Senior Medical, Atlanta, GA, USA.
Background: Patterns of human movement evolve as an individual experiences the progression from cognitively intact (CIN) to mild cognitive impairment (MCI) and finally dementia and Alzheimer's Disease (AD). Quantification of movement with the goal of identifying MCI though step counts alone do not take into consideration the floor layout of a home. Cyclomatic complexity is an approach to normalizing differences in the individual's living space to better predict the transition from CIN to MCI.
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