Spiral wave induced numerically using electrical stimulation and comparison with experimental results.

Annu Int Conf IEEE Eng Med Biol Soc

Laboratoire LE2I UMR CNRS 5158, Université de Bourgogne, 9 avenue Alain Savary, BP47870, 21078 Dijon, France.

Published: March 2011

Experiments in vitro on a Microelectrode Array (MEA) platform show that electrical stimulation can provoke the generation of spiral waves in cardiac tissue. Nevertheless, the conditions leading to this artificial fibrillation state remain unclear. In order to have a better understanding of this phenomenon, a numerical simulation study has been conducted. The results obtained with a two-dimensional FitzHugh-Nagumo model proved that it is possible to create spiral waves by adding a stimulation current under certain conditions, which are made explicit.

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http://dx.doi.org/10.1109/IEMBS.2010.5626540DOI Listing

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